Table 3 Subgroup analysis to identify the patients who benefit from adjuvant chemotherapy
RNU only | RNU + AC | HR | 95% CI | P value | |
|---|---|---|---|---|---|
age | |||||
≤ 70 | 14/48 | 7/49 | 0.46 | 0.18–1.1 | 0.099 |
> 70 | 14/27 | 9/26 | 0.56 | 0.24–1.3 | 0.19 |
pT2 | |||||
≤ 2 | 4/12 | 4/15 | 0.66 | 0.16–2.6 | 0.56 |
3 | 22/60 | 12/59 | 0.51 | 0.25–1.0 | 0.066 |
4 | 2/3 | 0/1 | – | – | 1 |
Na-Hb score | |||||
0 | 5/30 | 2/19 | 0.84 | 0.16–4.3 | 0.84 |
1–2 | 23/45 | 12/54 | 0.30 | 0.15–0.61 | 0.001 |
ECOG PS | |||||
0–1 | 27/72 | 16/72 | 0.542 | 0.292–1.01 | 0.053 |
≥ 2 | 1/3 | 0/3 | – | – | 1 |
LVI | |||||
– | 4/24 | 2/23 | 0.483 | 0.088–2.64 | 0.40 |
+ | 24/51 | 14/52 | 0.51 | 0.26–0.98 | 0.046 |
Grade | |||||
1–2 | 3/25 | 3/24 | 0.99 | 0.20–4.9 | 0.99 |
3 | 25/50 | 13/51 | 0.41 | 0.21–0.81 | 0.011 |