Table 1 Characteristics of the included studies on PNI in patients with PCa following RP
Author | Year | Country | Recruitment period | sample size | Age (years) | p-PSA (ng/ml) | GS≥7 (n.%) | Pathological stage ≥ pT2 (n.%) | PNI (n.%) | Follow-up (months) | NOS (score) |
|---|---|---|---|---|---|---|---|---|---|---|---|
Ito et al. [32] | 2003 | Japan | 1989-1998 | 82 | Mean 66.5 | Mean 17.2 | 47 (57.3%) | 50(61%) | 64 (78%) | Mean 21.7 | 7 |
Jeon et al. [25] | 2009 | Korea | 1995-2004 | 237 | Mean 64.5 | Mean 11.2 | 183 (77.2%) | 237(100%) | 100 (42.2%) | Median 21.6 | 8 |
Lee et al. [18] | 2010 | Korea | 1999-2010 | 361 | Mean 69 | Mean 15.6 | 160 (44.3%) | 361(100%) | 188 (52.1%) | Mean 42.2 | 7 |
Loeb et al. [33] | 2010 | USA | 2002-2007 | 1256 | Mean 56.1 | Mean 5.7 | 293 (23.3%) | 297(23.6%) | 188 (15%) | Mean 33.6 | 8 |
Muramaki et al. [34] | 2010 | Japan | 2003-2007 | 174 | Mean 67.5 | Mean 9.5 | 150 (86.2%) | 128(73.6%) | 107 (83.6%) | Median 44.3 | 7 |
Jung et al. [35] | 2011 | Korea | 2005-2009 | 407 | Mean 63.2 | Mean 10.3 | 247 (60.7%) | 307(75.4%) | 129 (31.7%) | Median 18.4 | 7 |
Lee et al. [36] | 2015 | Korea | 2011-2012 | 752 | Mean 66 | Mean 9.3 | 605 (80.5%) | 260(34.6%) | 483 (64.2%) | Mean 28.3 | 7 |
Reeves et al. [27] | 2015 | Australia | 2005-2012 | 1497 | Median 62 | NR | 1306 (87.2%) | 1173 (78%) | 1173 (78.4%) | Median 14 | 7 |
Watkins et al. [37] | 2015 | USA | 2003-2010 | 279 | Median 62 | Median 5.5 | 80 (28.7%) | 279(100%) | 193 (69%) | Median 52.7 | 8 |
Zhu et al. [13] | 2016 | China | 2002-2014 | 502 | Median 67 | Median 12.9 | 248 (49.4%) | 502(100%) | 411 (81.9%) | Median 28.6 | 7 |
Kang et al. [24] | 2016 | Korea | 2003-2014 | 2034 | Median 67 | Median 7.4 | 1726 (84.9%) | NR | 252 (12.4%) | Median 48 | 7 |
Kim et al. [38] | 2016 | Korea | 2005-2016 | 2316 | Median 65 | Median 7.4 | 1621 (69.9%) | 2316(100%) | NR | Median 60 | 8 |
Aoun et al. [5] | 2017 | Belgium | 1990-2013 | 910 | Mean 64 | Median 6.8 | 189 (20.8%) | 910(100%) | 305 (33.5%) | Median 108 | 7 |