Table 3 Summary and subgroup analyses of the eligible studies
Analysis specification | No. of studies | Study heterogeneity | Effects model | Pooled HR(95% CI) | P-Value | |
|---|---|---|---|---|---|---|
I2(%) | P heterogeneity | |||||
Radical prostatectomy | ||||||
Overall | 13 | 48.6 | 0.025 | Random | 1.23 (1.11, 1.36) | <0.001 |
Geographical region | ||||||
 Asia | 9 | 57.8 | 0.013 | Random | 1.26 (1.10, 1.45) | 0.001 |
 Other regions | 4 | 6 | 0.363 | Fixed | 1.23 (1.11, 1.36) | 0.027 |
Age(years) | ||||||
 ≥65 | 7 | 67.2 | 0.006 | Random | 1.25 (1.04, 1.50) | 0.015 |
 <65 | 6 | 0 | 0.425 | Fixed | 1.20 (1.08, 1.32) | <0.001 |
p-PSA(ng/ml) | ||||||
 ≥10 | 4 | 44.4 | 0.126 | Fixed | 1.21 (1.01, 1.46) | 0.037 |
 <10 | 8 | 57.8 | 0.027 | Random | 1.28 (1.10, 1.49) | 0.001 |
Sample size(cases) | ||||||
 ≥ 500 | 7 | 45.7 | 0.101 | Fixed | 1.23 (1.03, 1.47) | 0.002 |
 < 500 | 6 | 57.5 | 0.028 | Random | 1.24 (1.08, 1.41) | 0.026 |
Median follow-up( months) | ||||||
 ≥ 30 | 7 | 34.9 | 0.162 | Fixed | 1.34 (1.12, 1.61) | 0.001 |
 < 30 | 6 | 57.9 | 0.036 | Random | 1.16 (1.11, 1.36) | 0.014 |
Radiotherapy | ||||||
Overall | 6 | 34.7 | 0.176 | Fixed | 1.22 (1.12, 1.34) | <0.001 |
Age(years) | ||||||
 ≥65 | 4 | 44.8 | 0.143 | Fixed | 1.21 (1.11, 1.33) | <0.001 |
 <65 | 2 | 38.8 | 0.201 | Fixed | 1.45 (0.93, 2.24) | 0.097 |
Sample size(cases) | ||||||
 ≥ 500 | 3 | 0 | 0.495 | Fixed | 1.20 (1.09, 1.31) | <0.001 |
 < 500 | 3 | 31.0 | 0.235 | Fixed | 1.68 (1.18, 2.39) | 0.004 |