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Fig. 3 | BMC Urology

Fig. 3

From: miR-221-5p enhances cell proliferation and metastasis through post-transcriptional regulation of SOCS1 in human prostate cancer

Fig. 3

SOCS1 is a direct downstream target for miR-221-5p. a The expression level of SOCS1 in tumor tissues and adjacent tissues of prostate cancer patients. b Model of the construction of wild-type or mutant SOCS1 3’UTR vectors. c Luciferase activity assays of luciferase vectors with wild-type or mutant SOCS1 3’UTR were performed after co-transfection with miR-221-5p mimic or negative control (NC). The luciferase activity was normalised to Renilla luciferase activity. d, e Western blot assays of SOCS1 protein in PC3 cells after infection with miR-221-5p overexpression or silening lentivirus. *P < 0.05, **P < 0.01, ***P < 0.001

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BMC Urology

ISSN: 1471-2490

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