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Table 2 Urodynamic parameters at baseline and after 8 weeks of therapy

From: Silodosin 8 mg improves benign prostatic obstruction in Caucasian patients with lower urinary tract symptoms suggestive of benign prostatic enlargement: results from an explorative clinical study

 

Baseline

8 weeks

P value

Volume at first desire to void, mL, mean (SD)

105.7 (36.6)

130.3 (42.5)

0.004

Maximum cystometric capacity, mL, mean (SD)

229.7 (70.0)

257.5 (71.2)

0.0717

Bladder compliance (mL/ cmH2O), mean (SD)

17.2 (27.7)

26.5 (38.9)

0.2851

DO, n (%)

4 (13.3)

2 (6.7)

0.3173

Amplitude of the largest DO contraction, cmH2O, mean (SD)

9.0 (25.0)

4.3 (12.1)

0.3098

Pdet Qmax, cmH2O, mean (SD)

86.1 (19.7)

58.2 (17.3)

< 0.0001

Pdetmax, cmH2O, mean (SD)

99.6 (23.5)

72.0 (22.4)

< 0.0001

Detrusor opening pressure, cmH2O, mean (SD)

72.1 (31.0)

50.3 (23.1)

0.0031

Qmax, mL/s, mean (SD)

7.8 (3.1)

9.5 (3.8)

0.015

BOOI, mean (SD)

70.6 (18.9)

39.2 (18.3)

< 0.0001

BOOI< 20 n, (%)

0 (0)

4 (13.3)

 

BOOI 20–40 n, (%)

0 (0)

12 (40.0)

 

BOOI> 40 n, (%)

30 (100)

14 (46.7)

 

Bladder Contractility Index, mean (SD)

121 (34.7)

105.6 (26.5)

0.0274

PVR volume, mL, mean (SD)

71.1 (33.1)

52.5 (23.2)

< 0.0001

  1. BOOI Bladder Outlet Obstruction Index, DO Detrusor Overactivity, Pdet max Maximum Detrusor Pressure, PdetQ max Detrusor Pressure at Qmax, PFS Pressure/Flow Study, PVR Post-Void Residual Volume, Q max Maximum urine flow rate, SD Standard Deviation
  2. Mc Nemar’s Test
  3. paired T Test