Author, year | Study design | Subjects in the cases group (n) | Findings |
---|---|---|---|
Gosling, 1986 [39] | Case-control | 19 | ↓ autonomic nerve supply |
Chapple, 1992 [41] | Case-control | 19 | ↓ density of innervation by vasoactive intestinal polypeptide, calcitonin gene-related peptide, substance P and somatostatin immunoreactive nerve fibers in the obstructed bladder. |
Cumming, 1992 [40] | Case-control | 10 | ↓innervation |
Elbadawi, 1993 [12] | Case control | 7 | ↑axon degeneration in patients with impaired detrusor contractility |
Steers, 1991 [42] | Case-control | – | ↑ NGF in grossly hypertrophied human bladders |
Barbosa, 2017 [37] | Case-control | 43 | ↑ NGF receptor expression in smokers and dyslipidemic patients |