Prognostic significance of the combination of preoperative hemoglobin and albumin levels and lymphocyte and platelet counts (HALP) in patients with renal cell carcinoma after nephrectomy

Table 3 Univariate and multivariate analyses of factors associated with cancer-specific survival for RCC patients

Variable	Univariate analysis P	Multivariate analysis
Variable	Univariate analysis P	HR (95% CI)	P
Age (>65 vs ≤65)	0.287
Gender (female vs male)	0.226
Histology subtype (non-ccRCC vs ccRCC)	0.385
ASA grade (3 + 4 vs 1 + 2)	0.964
Fuhrman grade (3 + 4 vs 1 + 2)	< 0.001	1.767 (1.177–2.652)	0.006
T stage (3 + 4 vs 1 + 2)	< 0.001	3.890 (2.510–6.030)	< 0.001
N status (positive/negative)	< 0.001	2.480 (1.526–4.032)	< 0.001
M status (positive vs negative)	< 0.001	4.728 (3.090–7.233)	< 0.001
Sarcomatous differentiation (present vs absent)	< 0.001
Lymphovascular invasion (present vs absent)	< 0.001
Necrosis (present vs absent)	< 0.001
Hypoalbuminemia (present vs absent)	< 0.001
Anemia (present vs absent)	< 0.001
NLR (high vs low)	< 0.001
PLR (high vs low)	< 0.001
HALP (low vs high)	< 0.001	1.838 (1.260–2.681)	0.002

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