Table 2 Molecular biomarkers
All | Renal pelvis | Ureter | Chi-square or Z | p value | |
|---|---|---|---|---|---|
Patients, no. (%) | 612 (100) | 341 (55.7) | 271 (44.3) | ||
TMEFF2, no. (%) | 6.717 | 0.011* | |||
Unmethylated | 346 (56.5) | 177 (51.9) | 169 (62.4) | ||
Methylated | 266 (43.5) | 164 (48.1) | 102 (37.6) | ||
HSPA2, no. (%) | 3.172 | 0.083 | |||
Unmethylated | 355 (58.0) | 187 (54.8) | 168 (62.0) | ||
Methylated | 257 (42.0) | 154 (45.2) | 103 (38.0) | ||
GDF15, no. (%) | 57.000 | < 0.001* | |||
Unmethylated | 304 (49.7) | 123 (36.1) | 181 (66.8) | ||
Methylated | 308 (50.3) | 218 (63.9) | 90 (33.2) | ||
RASSF1A, no. (%) | 20.465 | < 0.001* | |||
Unmethylated | 448 (73.2) | 225 (66.0) | 223 (82.3) | ||
Methylated | 164 (26.8) | 116 (34.0) | 48 (17.7) | ||
SALL3, no. (%) | 7.119 | 0.008* | |||
Unmethylated | 403 (65.8) | 209 (61.3) | 194 (71.6) | ||
Methylated | 209 (34.2) | 132 (38.7) | 77 (28.4) | ||
VIM, no. (%) | 2.347 | 0.128 | |||
Unmethylated | 219 (35.8) | 113 (33.1) | 106 (39.1) | ||
Methylated | 393 (64.2) | 228 (66.9) | 165 (60.9) | ||
ABCC6, no. (%) | 4.719 | 0.037* | |||
Unmethylated | 523 (85.5) | 282 (82.7) | 241 (88.9) | ||
Methylated | 89 (14.5) | 59 (17.3) | 30 (11.1) | ||
CDH1, no. (%) | 0.208 | 0.728 | |||
Unmethylated | 524 (85.6) | 290 (85.0) | 234 (86.3) | ||
Methylated | 88 (14.4) | 51 (15.0) | 37 (13.7) | ||
THBS1, no. (%) | 0.005 | 1.000 | |||
Unmethylated | 457 (74.7) | 255 (74.8) | 202 (74.5) | ||
Methylated | 155 (25.3) | 86 (25.2) | 69 (25.5) | ||
BRCA1, no. (%) | 0.460 | 0.523 | |||
Unmethylated | 504 (82.4) | 284 (83.3) | 220 (81.2) | ||
Methylated | 108 (17.6) | 57 (16.7) | 51 (18.8) | ||
Presence of hypermethylation in any gene, no. (%) | 9.420 | 0.003* | |||
Unmethylated | 70 (11.4) | 27 (7.9) | 43 (15.9) | ||
Methylated | 542 (88.6) | 314 (92.1) | 228 (84.1) | ||
Mean methylated genes | 3.71 ± 2.33 | 2.85 ± 2.19 | −4.503 | < 0.001* | |
Number of methylated genes, no. (%) | 17.202 | < 0.001* | |||
0–2 | 254 (41.5) | 118 (34.6) | 136 (50.2) | ||
3–5 | 243 (39.7) | 145 (42.5) | 98 (36.2) | ||
6–10 | 115 (18.8) | 78 (22.9) | 37 (13.7) | ||
Number of methylated genes, no. (%) in Ta-1 | 11.251 | 0.004* | |||
All | 206 (100) | 113 (54.9) | 93 (45.1) | ||
0–2 | 95 (46.1) | 41 (36.3) | 54 (58.1) | ||
3–5 | 80 (38.8) | 49 (43.4) | 31 (33.3) | ||
6–10 | 31 (15.0) | 23 (20.4) | 8 (8.6) | ||
Number of methylated genes, no. (%) in T2–4 | 7.318 | 0.026* | |||
All | 406 (100) | 228 (56.2) | 178 (43.8) | ||
0–2 | 159 (39.2) | 77 (33.8) | 82 (46.1) | ||
3–5 | 163 (40.1) | 96 (42.1) | 67 (37.6) | ||
6–10 | 84 (20.7) | 55 (24.1) | 29 (16.3) | ||
Number of methylated genes, no. (%) in G1–2 | 18.433 | < 0.001* | |||
All | 353 (100) | 222 (62.9) | 131 (37.1) | ||
0–2 | 156 (44.2) | 80 (36.0) | 76 (58.0) | ||
3–5 | 141 (39.9) | 97 (43.7) | 44 (33.6) | ||
6–10 | 56 (15.9) | 45 (20.3) | 11 (8.4) | ||
Number of methylated genes, no. (%) in G3 | 4.449 | 0.108 | |||
All | 259 (100) | 119 (45.9) | 140 (54.1) | ||
0–2 | 98 (37.8) | 38 (31.9) | 60 (42.9) | ||
3–5 | 102 (39.4) | 48 (40.3) | 54 (38.6) | ||
6–10 | 59 (22.8) | 33 (27.7) | 26 (18.6) |