Skip to main content

Table 2 Characteristics of included studies in meta-analysis

From: Role of lymph node dissection in the management of upper tract urothelial carcinomas: a meta-analysis

Study Type of study Gender Patients (n) Follow-up median (month) Median age (year) Node status (overall)/ LND or NLND Extent of LND Tumor location Pathologic tumor stage Tumor grade Outcome
Kondo T et al 2014 [31] Prospective Male 112
Female 54
166 23.7 72.4 pN0 69 pNx 86 pN+  11 Renal pelvis tumor: LN from the renal hilar to the inferior mesenteric artery.
Tumor of upper 2/3 ureter: LN from the renal hilar to the aortic bifurcation.
Tumor of lower 1/3 ureter: the ipsilateral pelvic LN
Renal pelvis 90
Ureter 76
≤pT1 62
pT2 27
pT3 72
pT4 5
Low 71
High 95
CSS
Ouzzane A et al 2013 [16] Retrospective Male 484
Female 228
714 27.0 70.0 pN0 204 pNx 460 pN+  50 NA Renal pelvis 388
Pelvis+ureter 90
Multifocal 236
pTa/Tis 209
pT1 168
pT2 74
pT3 224
pT4 39
G1 71
G2 244
G3 399
CSS, RFS
Mason RJ et al. 2012 [15] Retrospective Male 654
Female 375
1029 19.8 68.6 pN0 199 pNx 753 pN+  77 NA Renal pelvis 538
Pelvis+ureter 213
Ureter 250
pTa/Tis 108
pT1 463
pT2 160
pT3 244
pT4 54
Low 340
High 689
CSS, RFS
Burger M et al 2011 [30] Retrospective Male 542
Female 243
785 34.0 68.0 pN0 136 pNx 595 pN+  54 Hilar & regional LN adjacent to ipsilateral great vessel NA pTa 165
pTis 10
pT1 196
pT2 148
pT3 222
pT4 44
G1 100
G2 226
G3 459
CSS, RFS
Abe T et al 2010 [29] Retrospective Male 195
Female 98
293 NA 69.2 pN0 130 pNx 141 pN+  22 Tumor of renal pelvis tumor & upper 2/3 ureter: Hilar & regional LN adjacent to ipsilateral great vessel
Lower ureteral tumor: ipsilateral pelvic LN
Renal pelvis 157
Pelvis+ureter 24
Ureter 112
pTa/Tis 53
pT1 66
pT2 56
pT3 101
pT4 17
Low 185
High 108
RFS
Lughezzani et al 2010 [14] Retrospective Male 1666
Female 1158
2824 43.0 72.0 pN0 1835 pNx 747 pN+  242 NA Renal pelvis 1913
Ureter 911
pT1 867
pT2 500
pT3 584
pT4 873
G1 156
G2 935
G3 1234
G4 499
CSS
Roscigno M et al 2009 [28] Retrospective NA 1130 45.0 69.1 pN0 412 pNx 578 pN+  140 Renal pelvis and proximally ureteral tumor: LN from the renal hilar to the inferior mesenteric artery
Mid and lower ureteral tumors:
LN from the renal hilar to the bifurcation of the common iliac artery and ipsilateral pelvic LN
NA pT1 317
pT2 269
pT3–4544
Low 291
High 839
CSS
Kondo T et al. 2007 [27] Retrospective Male 113
Female 56
169 37.3 67.5 LND 81 NLND 88 Renal pelvis tumor: LN from the renal hilar to the inferior mesenteric artery
Tumor of upper 2/3 ureter: LN from the renal hilar to the aortic bifurcation
Tumor of lower 1/3 ureter: ipsilateral pelvic LN
Renal pelvis 100
Upper ureter 9
Midureter 20
Lower ureter 40
≤pT1 45
pT2 34
pT3 79
pT4 9
NA CSS
Secin FP et al. 2007 [26] Retrospective Male 166
Female 86
252 37.2 69.0 pN0 105 pNx 119 pN+  28 NA NA pTa 71
pTis 12
pT1 46
pT2 35
pT3 72
pT4 8
G1 64
G2 38
G3 143
CSS
Brausi MA et al 2007 [25] Retrospective Male 59
Female 23
82 64.7 LND 67.8
NLND 67.1
LND 40 NLND 42 Renal pelvis and upper ureteral tumor: LN from the renal hilar to the inferior mesenteric artery
Mid ureteral tumors: LN from the renal hilar to the bifurcation of the common iliac artery
Lower ureteral tumor: ipsilateral pelvic LN
Renal pelvis 47
Pelvis+ureter 7
Ureter 28
pT2 38
pT3 36
pT4 8
G2 44
G3 38
CSS
Miyake H et al.. 1998 [24] Retrospective Male 53
Female 19
72 49 LND 64
NLND 67
LND 35 NLND 38 Renal pelvis and upper ureteral tumor: LN from the renal hilar to the inferior mesenteric artery
Mid ureteral tumor: LN from the renal hilar to the bifurcation of the common iliac artery
Lower ureteral tumor: ipsilateral pelvic LN
Renal pelvis 40
Pelvis+ureter 3
Ureter 29
pTa 11
pT1 25
pT2 18
pT3 14
pT4 4
G1 12
G2 33
G3 37
CSS
  1. LND Lymph node dissection, NLND Non-LND, NA Not available, pN+ Positive lymph node, pN0 Negative lymph node, pNx Not undergo lymph node dissection, CSS cancer-specific survival, RFS recurrence-free survival