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Table 1 List of 114 cases of renal SS published in the literature

From: Primary synovial sarcoma of the kidney: a case report of complete pathological response at a Lebanese tertiary care center

Case Report/Series

Author/ Year of publication

No of cases

Age(Y)/Gender (M/F)

Presenting symptoms

Fusion gene Variant

Treatment

Outcome

1

Argani P et al.; 2000 [5]

17

10 M

7 F Median age: 35

Abdominal pain; hematuria; incidental finding for hypertension workup; other data not available

1: SYT-SSX1; 4: SYT-SSX2

Radical nephrectomy

N/A

2

Kim DH et al.; 2000 [17]

2

53/M

47/M

Rt flank pain

Rt flank pain, gross hematuria

SYT-SSX2;

Rt radical nephrectomy; Rt radical nephrectomy with IVC thrombectomy

No recurrence 6 mons later; lung mets 5 mons later, death 10mons post-op

3

Chen S et al.; 2001 [18]

1

48/M

Hematuria

SYT-SSX 2

Lt radical nephroureterectomy; Radiation to surgical bed; 4 cycles of ifosfamide and Doxorubicin

N/A

4

Koyama S et al.; 2001 [8]

1

47/F

Right back pain

SYT-SSX 2

Rt radical nephrectomy

No recurrence 17 mons later

5

Bella AJ et al.; 2002 [25]

1

24/M

Gross hematuria

SYT-SSX t(X;18)

Rt radical nephrectomy, adjuvant Actinomycin + Vincristine

No clinical evidence of disease 18 mons after nephrectomy

6

Dai YC et al.; 2002 [26]

1

19/F

Abdominal Pain, 3 mons of amenorrhea

SYT-SSX t(X;18)

Rt nephrectomy

Recurrence of tumor in retroperitoneum and abdominal wall 9 mons after surgery

7

Vesoulis Z et al.; 2003 [27]

1

38/M

Acute abdominal pain

SST-SSX1

Lt radical nephrectomy

N/A

8

Moch H et al.; 2003 [28]

2

47/M

56/F

Renal mass

SST-SSX1/ SYT-SSX2

Nephrectomy/ Rt nephrectomy

Local recurrence 11 years later/ N/A

9

Chen PC et al.; 2003 [29]

1

19/M

left flank pain and intermittent hematuria

N/A

Lt radical nephrectomy + IVC thrombectomy; adjuvant Ifosfamide + Etoposide

died of sepsis 1 month after surgery

10

Park SJ et al.; 2004 [9]

1

32/F

Intermittent abdominal pain

N/A

Lt radical nephrectomy + thormbectomy; 6 cycles Ifosfamide + Doxorubicin

Metastasis to lung 4 mons post-op, complete remission after chemotherapy

11

Jun SY t al; 2004 [30]

3

27, 35/F

26/M

Rt flank pain

SYT-SSX2

Rt radical nephrectomies

1F: disease free 5 mons post-op; 2F: lumbar vertebral mets 5 mons post-op, 6 mons disease free post-resection; 3 M: bilateral hemothorax; death 34 days post-op

12

Tornkvist M et al.; 2004 [24]

1

34/F

N/A

SYT-SSX 2

Rt nephrectomy, chemotherapy

Visceral recurrence; lung metastases

13

Schaal CH et al.; 2004 [14]

1

27/M

Hematuria and large abdominal mass

N/A

Ifosfamide and Adriamycin, followed by Rt Radical nephrectomy

No recurrence after one year

14

Shao L et al.; 2004 [31]

4

N/A

N/A

N/A

N/A

N/A

15

Shannon BA et al.; 2005 [32]

1

60/M

Hematuria

SYT-SSX 2

Rt radical nephrectomy, Imatinib, 5 cycles of adjuvant chemotherapy

Pulmonary metastasis 6 mons after surgery; death 12 mons later

16

Perlmutter AE et al.; 2005 [33]

1

61/F

Right flank pain and gross hematuria

SYT-SSX 2

Rt nephrectomy, refused adjuvant chemotherapy

No recurrence 5 mons post-surgery

17

Stage et al.; 2005 [34]

1

51/F

Renal masses incidentally found

N/A

N/A

N/A

18

Paláu L MA et al.; 2007 [35]

1

71/F

Flank pain and gross hematuria

SYT-SSX 2

Lt nephrectomy

Recovery in 22 mons after surgery

19

Drozenova et al.; 2008 [36]

2

33/M

57/F

Rt flank pain

Lt flank pain

SYT-SSX1/ SYT-SSX1

Rt Radical nephrectomy/ Lt Radical nephrectomy

Local recurrence and lung mets; death 6 mons later/ N/A

20

Mirza M et al.; 2008 [37]

1

17/M

Flank pain and gross hematuria

SYT-SSX 2

Lt radical nephrectomy

No recurrence 1 year later

21

Gabilondo F et al.; 2008 [38]

1

32/F

Mild abdominal pain; gross hematuria

SYT-SSX t(X;18)

Rt radical nephrectomy

N/A

22

Zakhary MM et al.; 2008 [39]

1

52/F

Right flank pain

N/A

Rt nephrectomy

N/A

23

Chung SD et al.; 2008 [40]

2

30/F

49/F

Rt flank pain

Lt loin pain

SYT-SSX1

Rt radical nephrectomy/ Lt radical nephrectomy

No recurrence 15 mons post-op/ No recurrence 27 mons post-op

24

Erturhan S et al.; 2008 [41]

1

59/M

Right lumbar pain and palpable mass

N/A

N/A

N/A

25

Divetia M et al.; 2008 [42]

7

2-M

5-F

(15–46 years)

Abdominal lump, hematuria

3 SYT-SSX1/

1 SYT-SSX2

Radical nephrectomy

Lung mets in 2 patients; death at 6 and 12 mons, respectively

26

Dassi V et al.; 2009 [43]

1

20/F

Flank pain

SYT-SSX t(X;18)

Lt radical nephrectomy

N/A

28

Kawahara et al.; 2009 [44]

1

40/F

Abdominal pain

SYT-SSX 1

Radical nephrectomy

N/A

29

Long JA et al.; 2009 [45]

3

(Age range: 27–33 years)

Back pain and spontaneous rupture

SYT-SSX t(X;18)

2 Rt radical nephrectomy; 1 Lt radical nephrectomy

2 patients: total remission 25 mons post-op; 1 patient: death 24 mons post-op

30

Wezel F et al.; 2010 [46]

1

47/M

Hematuria, abdominal pain, weight loss

SYT-SSX t(X;18)

Nephrectomy

No recurrence 18 weeks after surgery

31

Wang Z-H et al.; 2009 [47]

4

2/F

2/M

32 to 48 years

Low back pain, hematuria

SYT-SSX1

Radical nephrectomy; 3 Lt side, 1 Rt side

Liver + lung metastasis; death at 5, 8, 18, and 21 mons post-op, respectively

32

Kageyama S et al.; 2010 [48]

1

67/M

Gross hematuria and right flank pain

SYT-SSX 2

Rt nephroureterectomy; Ifosfamide and Etoposide regimen

Tumor recurrence 33 mons post nephrectomy; Liver mets; death 4 years later

33

Tan YS et al.; 2010 [49]

4

N/A

N/A

N/A

N/A

N/A

34

Romero-Rojas AE et al.; 2013 [50]

1

15/M

Lt abdominal pain; weight loss

N/A

Neoadjuvant chemotherapy followed by Lt radical nephrectomy

Death 1.8 years later

35

Lakshmaiah KC et al.; 2010 [51]

2

50/F

45/M

Rt flank pain/

Lt flank pain, hematuria

SYT-SSX2/

NOT DONE

Radical nephrectomy

No recurrence 2 years post-op/ lost to follow-up

36

Kataria et al.; 2010 [52]

1

52/F

Renal mass

SYT-SSX 2

Radical nephrectomy IVC thrombectomy; adjuvant chemo-radiation

Mets to lung

37

Grampurohit VU et al.; 2011 [53]

1

21/F

Fever, hematuria; right flank pain

SYT-SSX t(X;18)

Rt nephrectomy

No recurrence 6 mons post-surgery

38

Ozkan EE et al.; 2011 [20]

1

68/F

Right flank pain and abdominal distention

N/A

Rt nephroureterectomy, 4 cycles Ifosfamide and Doxorubicin

No recurrence one year later

39

Karafin M et al.; 2011 [54]

3

39/F

41/M

53/M

N/A

SYT-SSX2

SYT-SSX2

N/A

N/A

N/A

40

Nishida T et al.; 2011 [55]

1

63/F

Dysuria, hematuria

SYT-SSX 1 & 2

Rt Radical nephrectomy

No recurrence one year postop

41

Pitino A et al.; 2011 [8]

1

67/M

Lumbar pain, gross hematuria

SYT-SSX 2

Lt Nephroureterectomy; adjuvant Epirubicin post-op

Local recurrence of disease 24 mons post- surgery

42

Bakhshi et al.; 2012 [56]

1

33/F

Abdominal pain and gross hematuria

SYT-SSX 2

Lt radical nephrectomy; external radiotherapy

No recurrence at 2 years

43

Lopes et al.; 2013 [3]

1

19/M

Lumbar pain, gross hematuria

Negative translocation

Lt nephrectomy, thrombectomy; 5 cycles of doxorubicin

Lung mets several mons post-op

44

Pereira E Silva R et al.; 2013 [57]

1

17/M

Incidental large renal mass after workup for secondary hypertension

Negative translocation

Radical nephrectomy followed by ifosfamide

No recurrence 29 mons later

45

Marković-Lipkovski J et al.; 2013 [12]

1

38/M

Rt flank pain; fever; hematuria

SYT-SSX2

Rt radical nephrectomy

Died three mons later

46

Moorthy et al.; 2014 [58]

1

46/M

Flank pain

SYT-SSX 2

Lt radical nephrectomy

N/A

47

Majumber et al.; 2014 [59]

1

46/F

Flank pain, hematuria

N/A

Rt radical nephrectomy

No evidence of disease after 2 mons follow up

48

Schoolmeester JK et al.; 2014 [60]

16

9M/7F 17-78 yrs.; Median: 46 yrs

N/A; Rt: 10; Lt: 6;

SYT-SSX2: 10; SYT-SSX1: 5; 1: failed

14: Radical nephrectomy; 1: partial nephrectomy; 1: needle biopsy

6: death within 1–58 mons (mean 31mons); 5: no recurrence 12–77 mons (39 mons); 1: alive with spine mets 11mons later

49

Kim MS et al.; 2014 [61]

1

38/F

Lt flank pain

SYT-SSX2

Lap Lt radical nephrectomy followed by radiation to surgical bed

Recurrence at the distal ureter and uretero-vesical junction 6 mons post- surgery

50

Ozkanli SS et al.; 2014 [62]

1

45/M

Flank pain; macroscopic hematuria

SYT-SSX t(X;18)

Lt radical nephrectomy

N/A

51

Mishra S et al.; 2015 [13]

1

60/M

Flank pain, hematuria

SYT-SSX t(X;18)

Radical nephrectomy

N/A

52

Wang Z et al.; 2015 [61]

1

54/F

Flank pain, hematuria

SYT-SSX 1

Radical nephrectomy

No recurrence 12 mons post-surgery

53

Vedana M et al.; 2015 [63]

1

76/F

Flank pain; hematuria

SYT-SSX t(X;18)

Rt radical nephro-ureterectomy

No recurrence 20 mons post-surgery

54

Lv X-F et al.; 2015 [64]

5

2F/3M (15–43 yrs.; Median: 27.4 yrs)

N/A

N/A

N/A

N/A

55

Present case El Chediak A. et al.; 2016

1

26/M

Rt flank pain; hematuria

SYT-SSX2

Rt radical nephrectomy, Doxorubicin Ifosfamide

Lung metastasis 6 mons post nephrectomy; no recurrence one year post chemotherapy

  1. M Males, F Females, Yrs Years, Rt Right, Lt Left, Mets Metastasis, Mons Months, IVC Inferior vena cava, N/A Not Applicable