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Table 1 List of 114 cases of renal SS published in the literature

From: Primary synovial sarcoma of the kidney: a case report of complete pathological response at a Lebanese tertiary care center

Case Report/Series Author/ Year of publication No of cases Age(Y)/Gender (M/F) Presenting symptoms Fusion gene Variant Treatment Outcome
1 Argani P et al.; 2000 [5] 17 10 M
7 F Median age: 35
Abdominal pain; hematuria; incidental finding for hypertension workup; other data not available 1: SYT-SSX1; 4: SYT-SSX2 Radical nephrectomy N/A
2 Kim DH et al.; 2000 [17] 2 53/M
47/M
Rt flank pain
Rt flank pain, gross hematuria
SYT-SSX2; Rt radical nephrectomy; Rt radical nephrectomy with IVC thrombectomy No recurrence 6 mons later; lung mets 5 mons later, death 10mons post-op
3 Chen S et al.; 2001 [18] 1 48/M Hematuria SYT-SSX 2 Lt radical nephroureterectomy; Radiation to surgical bed; 4 cycles of ifosfamide and Doxorubicin N/A
4 Koyama S et al.; 2001 [8] 1 47/F Right back pain SYT-SSX 2 Rt radical nephrectomy No recurrence 17 mons later
5 Bella AJ et al.; 2002 [25] 1 24/M Gross hematuria SYT-SSX t(X;18) Rt radical nephrectomy, adjuvant Actinomycin + Vincristine No clinical evidence of disease 18 mons after nephrectomy
6 Dai YC et al.; 2002 [26] 1 19/F Abdominal Pain, 3 mons of amenorrhea SYT-SSX t(X;18) Rt nephrectomy Recurrence of tumor in retroperitoneum and abdominal wall 9 mons after surgery
7 Vesoulis Z et al.; 2003 [27] 1 38/M Acute abdominal pain SST-SSX1 Lt radical nephrectomy N/A
8 Moch H et al.; 2003 [28] 2 47/M
56/F
Renal mass SST-SSX1/ SYT-SSX2 Nephrectomy/ Rt nephrectomy Local recurrence 11 years later/ N/A
9 Chen PC et al.; 2003 [29] 1 19/M left flank pain and intermittent hematuria N/A Lt radical nephrectomy + IVC thrombectomy; adjuvant Ifosfamide + Etoposide died of sepsis 1 month after surgery
10 Park SJ et al.; 2004 [9] 1 32/F Intermittent abdominal pain N/A Lt radical nephrectomy + thormbectomy; 6 cycles Ifosfamide + Doxorubicin Metastasis to lung 4 mons post-op, complete remission after chemotherapy
11 Jun SY t al; 2004 [30] 3 27, 35/F
26/M
Rt flank pain SYT-SSX2 Rt radical nephrectomies 1F: disease free 5 mons post-op; 2F: lumbar vertebral mets 5 mons post-op, 6 mons disease free post-resection; 3 M: bilateral hemothorax; death 34 days post-op
12 Tornkvist M et al.; 2004 [24] 1 34/F N/A SYT-SSX 2 Rt nephrectomy, chemotherapy Visceral recurrence; lung metastases
13 Schaal CH et al.; 2004 [14] 1 27/M Hematuria and large abdominal mass N/A Ifosfamide and Adriamycin, followed by Rt Radical nephrectomy No recurrence after one year
14 Shao L et al.; 2004 [31] 4 N/A N/A N/A N/A N/A
15 Shannon BA et al.; 2005 [32] 1 60/M Hematuria SYT-SSX 2 Rt radical nephrectomy, Imatinib, 5 cycles of adjuvant chemotherapy Pulmonary metastasis 6 mons after surgery; death 12 mons later
16 Perlmutter AE et al.; 2005 [33] 1 61/F Right flank pain and gross hematuria SYT-SSX 2 Rt nephrectomy, refused adjuvant chemotherapy No recurrence 5 mons post-surgery
17 Stage et al.; 2005 [34] 1 51/F Renal masses incidentally found N/A N/A N/A
18 Paláu L MA et al.; 2007 [35] 1 71/F Flank pain and gross hematuria SYT-SSX 2 Lt nephrectomy Recovery in 22 mons after surgery
19 Drozenova et al.; 2008 [36] 2 33/M
57/F
Rt flank pain
Lt flank pain
SYT-SSX1/ SYT-SSX1 Rt Radical nephrectomy/ Lt Radical nephrectomy Local recurrence and lung mets; death 6 mons later/ N/A
20 Mirza M et al.; 2008 [37] 1 17/M Flank pain and gross hematuria SYT-SSX 2 Lt radical nephrectomy No recurrence 1 year later
21 Gabilondo F et al.; 2008 [38] 1 32/F Mild abdominal pain; gross hematuria SYT-SSX t(X;18) Rt radical nephrectomy N/A
22 Zakhary MM et al.; 2008 [39] 1 52/F Right flank pain N/A Rt nephrectomy N/A
23 Chung SD et al.; 2008 [40] 2 30/F
49/F
Rt flank pain
Lt loin pain
SYT-SSX1 Rt radical nephrectomy/ Lt radical nephrectomy No recurrence 15 mons post-op/ No recurrence 27 mons post-op
24 Erturhan S et al.; 2008 [41] 1 59/M Right lumbar pain and palpable mass N/A N/A N/A
25 Divetia M et al.; 2008 [42] 7 2-M
5-F
(15–46 years)
Abdominal lump, hematuria 3 SYT-SSX1/
1 SYT-SSX2
Radical nephrectomy Lung mets in 2 patients; death at 6 and 12 mons, respectively
26 Dassi V et al.; 2009 [43] 1 20/F Flank pain SYT-SSX t(X;18) Lt radical nephrectomy N/A
28 Kawahara et al.; 2009 [44] 1 40/F Abdominal pain SYT-SSX 1 Radical nephrectomy N/A
29 Long JA et al.; 2009 [45] 3 (Age range: 27–33 years) Back pain and spontaneous rupture SYT-SSX t(X;18) 2 Rt radical nephrectomy; 1 Lt radical nephrectomy 2 patients: total remission 25 mons post-op; 1 patient: death 24 mons post-op
30 Wezel F et al.; 2010 [46] 1 47/M Hematuria, abdominal pain, weight loss SYT-SSX t(X;18) Nephrectomy No recurrence 18 weeks after surgery
31 Wang Z-H et al.; 2009 [47] 4 2/F
2/M
32 to 48 years
Low back pain, hematuria SYT-SSX1 Radical nephrectomy; 3 Lt side, 1 Rt side Liver + lung metastasis; death at 5, 8, 18, and 21 mons post-op, respectively
32 Kageyama S et al.; 2010 [48] 1 67/M Gross hematuria and right flank pain SYT-SSX 2 Rt nephroureterectomy; Ifosfamide and Etoposide regimen Tumor recurrence 33 mons post nephrectomy; Liver mets; death 4 years later
33 Tan YS et al.; 2010 [49] 4 N/A N/A N/A N/A N/A
34 Romero-Rojas AE et al.; 2013 [50] 1 15/M Lt abdominal pain; weight loss N/A Neoadjuvant chemotherapy followed by Lt radical nephrectomy Death 1.8 years later
35 Lakshmaiah KC et al.; 2010 [51] 2 50/F
45/M
Rt flank pain/
Lt flank pain, hematuria
SYT-SSX2/
NOT DONE
Radical nephrectomy No recurrence 2 years post-op/ lost to follow-up
36 Kataria et al.; 2010 [52] 1 52/F Renal mass SYT-SSX 2 Radical nephrectomy IVC thrombectomy; adjuvant chemo-radiation Mets to lung
37 Grampurohit VU et al.; 2011 [53] 1 21/F Fever, hematuria; right flank pain SYT-SSX t(X;18) Rt nephrectomy No recurrence 6 mons post-surgery
38 Ozkan EE et al.; 2011 [20] 1 68/F Right flank pain and abdominal distention N/A Rt nephroureterectomy, 4 cycles Ifosfamide and Doxorubicin No recurrence one year later
39 Karafin M et al.; 2011 [54] 3 39/F
41/M
53/M
N/A SYT-SSX2
SYT-SSX2
N/A
N/A N/A
40 Nishida T et al.; 2011 [55] 1 63/F Dysuria, hematuria SYT-SSX 1 & 2 Rt Radical nephrectomy No recurrence one year postop
41 Pitino A et al.; 2011 [8] 1 67/M Lumbar pain, gross hematuria SYT-SSX 2 Lt Nephroureterectomy; adjuvant Epirubicin post-op Local recurrence of disease 24 mons post- surgery
42 Bakhshi et al.; 2012 [56] 1 33/F Abdominal pain and gross hematuria SYT-SSX 2 Lt radical nephrectomy; external radiotherapy No recurrence at 2 years
43 Lopes et al.; 2013 [3] 1 19/M Lumbar pain, gross hematuria Negative translocation Lt nephrectomy, thrombectomy; 5 cycles of doxorubicin Lung mets several mons post-op
44 Pereira E Silva R et al.; 2013 [57] 1 17/M Incidental large renal mass after workup for secondary hypertension Negative translocation Radical nephrectomy followed by ifosfamide No recurrence 29 mons later
45 Marković-Lipkovski J et al.; 2013 [12] 1 38/M Rt flank pain; fever; hematuria SYT-SSX2 Rt radical nephrectomy Died three mons later
46 Moorthy et al.; 2014 [58] 1 46/M Flank pain SYT-SSX 2 Lt radical nephrectomy N/A
47 Majumber et al.; 2014 [59] 1 46/F Flank pain, hematuria N/A Rt radical nephrectomy No evidence of disease after 2 mons follow up
48 Schoolmeester JK et al.; 2014 [60] 16 9M/7F 17-78 yrs.; Median: 46 yrs N/A; Rt: 10; Lt: 6; SYT-SSX2: 10; SYT-SSX1: 5; 1: failed 14: Radical nephrectomy; 1: partial nephrectomy; 1: needle biopsy 6: death within 1–58 mons (mean 31mons); 5: no recurrence 12–77 mons (39 mons); 1: alive with spine mets 11mons later
49 Kim MS et al.; 2014 [61] 1 38/F Lt flank pain SYT-SSX2 Lap Lt radical nephrectomy followed by radiation to surgical bed Recurrence at the distal ureter and uretero-vesical junction 6 mons post- surgery
50 Ozkanli SS et al.; 2014 [62] 1 45/M Flank pain; macroscopic hematuria SYT-SSX t(X;18) Lt radical nephrectomy N/A
51 Mishra S et al.; 2015 [13] 1 60/M Flank pain, hematuria SYT-SSX t(X;18) Radical nephrectomy N/A
52 Wang Z et al.; 2015 [61] 1 54/F Flank pain, hematuria SYT-SSX 1 Radical nephrectomy No recurrence 12 mons post-surgery
53 Vedana M et al.; 2015 [63] 1 76/F Flank pain; hematuria SYT-SSX t(X;18) Rt radical nephro-ureterectomy No recurrence 20 mons post-surgery
54 Lv X-F et al.; 2015 [64] 5 2F/3M (15–43 yrs.; Median: 27.4 yrs) N/A N/A N/A N/A
55 Present case El Chediak A. et al.; 2016 1 26/M Rt flank pain; hematuria SYT-SSX2 Rt radical nephrectomy, Doxorubicin Ifosfamide Lung metastasis 6 mons post nephrectomy; no recurrence one year post chemotherapy
  1. M Males, F Females, Yrs Years, Rt Right, Lt Left, Mets Metastasis, Mons Months, IVC Inferior vena cava, N/A Not Applicable