Case Report/Series | Author/ Year of publication | No of cases | Age(Y)/Gender (M/F) | Presenting symptoms | Fusion gene Variant | Treatment | Outcome |
---|---|---|---|---|---|---|---|
1 | Argani P et al.; 2000 [5] | 17 | 10Â M 7Â F Median age: 35 | Abdominal pain; hematuria; incidental finding for hypertension workup; other data not available | 1: SYT-SSX1; 4: SYT-SSX2 | Radical nephrectomy | N/A |
2 | Kim DH et al.; 2000 [17] | 2 | 53/M 47/M | Rt flank pain Rt flank pain, gross hematuria | SYT-SSX2; | Rt radical nephrectomy; Rt radical nephrectomy with IVC thrombectomy | No recurrence 6 mons later; lung mets 5 mons later, death 10mons post-op |
3 | Chen S et al.; 2001 [18] | 1 | 48/M | Hematuria | SYT-SSX 2 | Lt radical nephroureterectomy; Radiation to surgical bed; 4Â cycles of ifosfamide and Doxorubicin | N/A |
4 | Koyama S et al.; 2001 [8] | 1 | 47/F | Right back pain | SYT-SSX 2 | Rt radical nephrectomy | No recurrence 17 mons later |
5 | Bella AJ et al.; 2002 [25] | 1 | 24/M | Gross hematuria | SYT-SSX t(X;18) | Rt radical nephrectomy, adjuvant Actinomycin + Vincristine | No clinical evidence of disease 18 mons after nephrectomy |
6 | Dai YC et al.; 2002 [26] | 1 | 19/F | Abdominal Pain, 3 mons of amenorrhea | SYT-SSX t(X;18) | Rt nephrectomy | Recurrence of tumor in retroperitoneum and abdominal wall 9 mons after surgery |
7 | Vesoulis Z et al.; 2003 [27] | 1 | 38/M | Acute abdominal pain | SST-SSX1 | Lt radical nephrectomy | N/A |
8 | Moch H et al.; 2003 [28] | 2 | 47/M 56/F | Renal mass | SST-SSX1/ SYT-SSX2 | Nephrectomy/ Rt nephrectomy | Local recurrence 11Â years later/ N/A |
9 | Chen PC et al.; 2003 [29] | 1 | 19/M | left flank pain and intermittent hematuria | N/A | Lt radical nephrectomy + IVC thrombectomy; adjuvant Ifosfamide + Etoposide | died of sepsis 1Â month after surgery |
10 | Park SJ et al.; 2004 [9] | 1 | 32/F | Intermittent abdominal pain | N/A | Lt radical nephrectomy + thormbectomy; 6Â cycles Ifosfamide + Doxorubicin | Metastasis to lung 4 mons post-op, complete remission after chemotherapy |
11 | Jun SY t al; 2004 [30] | 3 | 27, 35/F 26/M | Rt flank pain | SYT-SSX2 | Rt radical nephrectomies | 1F: disease free 5 mons post-op; 2F: lumbar vertebral mets 5 mons post-op, 6 mons disease free post-resection; 3Â M: bilateral hemothorax; death 34Â days post-op |
12 | Tornkvist M et al.; 2004 [24] | 1 | 34/F | N/A | SYT-SSX 2 | Rt nephrectomy, chemotherapy | Visceral recurrence; lung metastases |
13 | Schaal CH et al.; 2004 [14] | 1 | 27/M | Hematuria and large abdominal mass | N/A | Ifosfamide and Adriamycin, followed by Rt Radical nephrectomy | No recurrence after one year |
14 | Shao L et al.; 2004 [31] | 4 | N/A | N/A | N/A | N/A | N/A |
15 | Shannon BA et al.; 2005 [32] | 1 | 60/M | Hematuria | SYT-SSX 2 | Rt radical nephrectomy, Imatinib, 5Â cycles of adjuvant chemotherapy | Pulmonary metastasis 6 mons after surgery; death 12 mons later |
16 | Perlmutter AE et al.; 2005 [33] | 1 | 61/F | Right flank pain and gross hematuria | SYT-SSX 2 | Rt nephrectomy, refused adjuvant chemotherapy | No recurrence 5 mons post-surgery |
17 | Stage et al.; 2005 [34] | 1 | 51/F | Renal masses incidentally found | N/A | N/A | N/A |
18 | Paláu L MA et al.; 2007 [35] | 1 | 71/F | Flank pain and gross hematuria | SYT-SSX 2 | Lt nephrectomy | Recovery in 22 mons after surgery |
19 | Drozenova et al.; 2008 [36] | 2 | 33/M 57/F | Rt flank pain Lt flank pain | SYT-SSX1/ SYT-SSX1 | Rt Radical nephrectomy/ Lt Radical nephrectomy | Local recurrence and lung mets; death 6 mons later/ N/A |
20 | Mirza M et al.; 2008 [37] | 1 | 17/M | Flank pain and gross hematuria | SYT-SSX 2 | Lt radical nephrectomy | No recurrence 1Â year later |
21 | Gabilondo F et al.; 2008 [38] | 1 | 32/F | Mild abdominal pain; gross hematuria | SYT-SSX t(X;18) | Rt radical nephrectomy | N/A |
22 | Zakhary MM et al.; 2008 [39] | 1 | 52/F | Right flank pain | N/A | Rt nephrectomy | N/A |
23 | Chung SD et al.; 2008 [40] | 2 | 30/F 49/F | Rt flank pain Lt loin pain | SYT-SSX1 | Rt radical nephrectomy/ Lt radical nephrectomy | No recurrence 15 mons post-op/ No recurrence 27 mons post-op |
24 | Erturhan S et al.; 2008 [41] | 1 | 59/M | Right lumbar pain and palpable mass | N/A | N/A | N/A |
25 | Divetia M et al.; 2008 [42] | 7 | 2-M 5-F (15–46 years) | Abdominal lump, hematuria | 3 SYT-SSX1/ 1 SYT-SSX2 | Radical nephrectomy | Lung mets in 2 patients; death at 6 and 12 mons, respectively |
26 | Dassi V et al.; 2009 [43] | 1 | 20/F | Flank pain | SYT-SSX t(X;18) | Lt radical nephrectomy | N/A |
28 | Kawahara et al.; 2009 [44] | 1 | 40/F | Abdominal pain | SYT-SSX 1 | Radical nephrectomy | N/A |
29 | Long JA et al.; 2009 [45] | 3 | (Age range: 27–33 years) | Back pain and spontaneous rupture | SYT-SSX t(X;18) | 2 Rt radical nephrectomy; 1 Lt radical nephrectomy | 2 patients: total remission 25 mons post-op; 1 patient: death 24 mons post-op |
30 | Wezel F et al.; 2010 [46] | 1 | 47/M | Hematuria, abdominal pain, weight loss | SYT-SSX t(X;18) | Nephrectomy | No recurrence 18Â weeks after surgery |
31 | Wang Z-H et al.; 2009 [47] | 4 | 2/F 2/M 32 to 48Â years | Low back pain, hematuria | SYT-SSX1 | Radical nephrectomy; 3 Lt side, 1 Rt side | Liver + lung metastasis; death at 5, 8, 18, and 21 mons post-op, respectively |
32 | Kageyama S et al.; 2010 [48] | 1 | 67/M | Gross hematuria and right flank pain | SYT-SSX 2 | Rt nephroureterectomy; Ifosfamide and Etoposide regimen | Tumor recurrence 33 mons post nephrectomy; Liver mets; death 4Â years later |
33 | Tan YS et al.; 2010 [49] | 4 | N/A | N/A | N/A | N/A | N/A |
34 | Romero-Rojas AE et al.; 2013 [50] | 1 | 15/M | Lt abdominal pain; weight loss | N/A | Neoadjuvant chemotherapy followed by Lt radical nephrectomy | Death 1.8Â years later |
35 | Lakshmaiah KC et al.; 2010 [51] | 2 | 50/F 45/M | Rt flank pain/ Lt flank pain, hematuria | SYT-SSX2/ NOT DONE | Radical nephrectomy | No recurrence 2Â years post-op/ lost to follow-up |
36 | Kataria et al.; 2010 [52] | 1 | 52/F | Renal mass | SYT-SSX 2 | Radical nephrectomy IVC thrombectomy; adjuvant chemo-radiation | Mets to lung |
37 | Grampurohit VU et al.; 2011 [53] | 1 | 21/F | Fever, hematuria; right flank pain | SYT-SSX t(X;18) | Rt nephrectomy | No recurrence 6 mons post-surgery |
38 | Ozkan EE et al.; 2011 [20] | 1 | 68/F | Right flank pain and abdominal distention | N/A | Rt nephroureterectomy, 4Â cycles Ifosfamide and Doxorubicin | No recurrence one year later |
39 | Karafin M et al.; 2011 [54] | 3 | 39/F 41/M 53/M | N/A | SYT-SSX2 SYT-SSX2 N/A | N/A | N/A |
40 | Nishida T et al.; 2011 [55] | 1 | 63/F | Dysuria, hematuria | SYT-SSX 1 & 2 | Rt Radical nephrectomy | No recurrence one year postop |
41 | Pitino A et al.; 2011 [8] | 1 | 67/M | Lumbar pain, gross hematuria | SYT-SSX 2 | Lt Nephroureterectomy; adjuvant Epirubicin post-op | Local recurrence of disease 24 mons post- surgery |
42 | Bakhshi et al.; 2012 [56] | 1 | 33/F | Abdominal pain and gross hematuria | SYT-SSX 2 | Lt radical nephrectomy; external radiotherapy | No recurrence at 2Â years |
43 | Lopes et al.; 2013 [3] | 1 | 19/M | Lumbar pain, gross hematuria | Negative translocation | Lt nephrectomy, thrombectomy; 5Â cycles of doxorubicin | Lung mets several mons post-op |
44 | Pereira E Silva R et al.; 2013 [57] | 1 | 17/M | Incidental large renal mass after workup for secondary hypertension | Negative translocation | Radical nephrectomy followed by ifosfamide | No recurrence 29 mons later |
45 | Marković-Lipkovski J et al.; 2013 [12] | 1 | 38/M | Rt flank pain; fever; hematuria | SYT-SSX2 | Rt radical nephrectomy | Died three mons later |
46 | Moorthy et al.; 2014 [58] | 1 | 46/M | Flank pain | SYT-SSX 2 | Lt radical nephrectomy | N/A |
47 | Majumber et al.; 2014 [59] | 1 | 46/F | Flank pain, hematuria | N/A | Rt radical nephrectomy | No evidence of disease after 2 mons follow up |
48 | Schoolmeester JK et al.; 2014 [60] | 16 | 9M/7F 17-78 yrs.; Median: 46 yrs | N/A; Rt: 10; Lt: 6; | SYT-SSX2: 10; SYT-SSX1: 5; 1: failed | 14: Radical nephrectomy; 1: partial nephrectomy; 1: needle biopsy | 6: death within 1–58 mons (mean 31mons); 5: no recurrence 12–77 mons (39 mons); 1: alive with spine mets 11mons later |
49 | Kim MS et al.; 2014 [61] | 1 | 38/F | Lt flank pain | SYT-SSX2 | Lap Lt radical nephrectomy followed by radiation to surgical bed | Recurrence at the distal ureter and uretero-vesical junction 6 mons post- surgery |
50 | Ozkanli SS et al.; 2014 [62] | 1 | 45/M | Flank pain; macroscopic hematuria | SYT-SSX t(X;18) | Lt radical nephrectomy | N/A |
51 | Mishra S et al.; 2015 [13] | 1 | 60/M | Flank pain, hematuria | SYT-SSX t(X;18) | Radical nephrectomy | N/A |
52 | Wang Z et al.; 2015 [61] | 1 | 54/F | Flank pain, hematuria | SYT-SSX 1 | Radical nephrectomy | No recurrence 12 mons post-surgery |
53 | Vedana M et al.; 2015 [63] | 1 | 76/F | Flank pain; hematuria | SYT-SSX t(X;18) | Rt radical nephro-ureterectomy | No recurrence 20 mons post-surgery |
54 | Lv X-F et al.; 2015 [64] | 5 | 2F/3M (15–43 yrs.; Median: 27.4 yrs) | N/A | N/A | N/A | N/A |
55 | Present case El Chediak A. et al.; 2016 | 1 | 26/M | Rt flank pain; hematuria | SYT-SSX2 | Rt radical nephrectomy, Doxorubicin Ifosfamide | Lung metastasis 6 mons post nephrectomy; no recurrence one year post chemotherapy |