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Table 1 Demographic data of the study population in all patients, patients aged 80 years or older and patients younger than 80 years. Comorbidity profile and tumor-related parameters as well as 90-day mortality and 5-year bladder cancer specific and competing mortality rates were less favorable in patients aged 80 years or older compared with their younger counterparts

From: Predicting 90-day and long-term mortality in octogenarians undergoing radical cystectomy

Parameter

Whole sample

< 80 years

80 years or older

p

Sample size

1184

1061

123

Mean follow-up (censored patients)

7.4 years

7.6 years

3.8 years

Median follow-up (censored patients)

6.2 years

6.5 years

2.5 years

Mean age

68.7 years

67.1 years

82.6 years

Bladder confined disease

684 (58%)

629 (59%)

55 (45%)

0.0020

Extravesical extension

500 (42%)

432 (41%)

68 (55%)

0.0020

Positive lymph nodes

308 (26%)

272 (26%)

36 (29%)

0.38

Extravesical extension or positive lymph nodes

576 (49%)

500 (47%)

76 (62%)

0.0021

Bladder confined disease and negative lymph nodes

608 (51%)

561 (53%)

47 (38%)

0.0021

ASA classes 3-4

493 (42%)

421 (40%)

72 (59%)

< 0.0001

Charlson score 2 or higher

449 (38%)

383 (36%)

66 (54%)

0.0001

Mean Charlson score

1.57

1.50

2.18

< 0.0001

Median Charlson score

1.00

1.00

2.00

CCS class 2 or higher

131 (11%)

109 (10%)

22 (18%)

0.0108

NYHA class 2 or higher

211 (18%)

177 (17%)

34 (28%)

0.0026

Female patients

255 (22%)

206 (19%)

49 (40%)

< 0.0001

Any neoadjuvant chemotherapy

55 (5%)

53 (5%)

2 (2%)

0.09

Adjuvant cisplatin-based chemotherapy

258 (22%)

257 (24%)

1 (1%)

< 0.0001

Current smokers

327 (28%)

315 (30%)

12 (10%)

< 0.0001

University degree/master craftsman

274 (23%)

250 (24%)

24 (20%)

0.31

Mean body mass index

27.0 kg/m2

27.0 kg/m2

26.7 kg/m2

0.26

Median body mass index

26.7 kg/m2

26.7 kg/m2

26.4 kg/m2

Continent diversion

390 (33%)

388 (37%)

2 (2%)

< 0.0001

Number of removed lymph nodes (if recorded)

18.4

18.8

15.2

< 0.0001

History of myocardial infarction

86 (7%)

72 (7%)

14 (11%)

0.06

Diabetes mellitus

288 (24%)

250 (24%)

38 (31%)

0.07

Lung disease

218 (18%)

196 (18%)

22 (18%)

0.87

Cerebrovascular disease

65 (5%)

56 (5%)

9 (7%)

0.35

Peripheral vascular disease

129 (11%)

111 (10%)

18 (15%)

0.16

Deaths from non-cancer causes

205

170

35

Deaths from bladder cancer

372

325

47

Deaths from second cancer

66

64

2

Deaths from unknown causes

7

5

2

90-day mortality

4.2%

3.7%

8.9%

< 0.0001

5-year bladder cancer-specific mortality

30.3%

28.9%

44.3%

0.0038

5-year competing (non-bladder cancer) mortality

14.1%

12.5%

28.7%

0.0005

  1. CCS Classification of angina pectoris of the Canadian Cardiovascular Society [21]; NYHA Classification of cardiac insufficiency of the New York Heart Association [22]; ASA American Society Association physical status classification [11]