Table 1 Inclusion and exclusion criteria

Inclusion Criteria

1. Patients ≥18 years old

2. Biopsy proven prostate cancer

3. Treatment by radical prostatectomy (open or robot-assisted)

4. Signed informed consent

Exclusion Criteria

1. PSA > 20 ng/mL and or clinical T3 rectal examination

2. Prostate volume above 80 mL measured on TRUS

3. Radiation therapy, focal therapy and/or chemotherapy for prostate cancer

4. Inability to undergo TRUS

5. Any form of hormonal therapy or androgen deprivation therapy within 6 months prior to procedure

6. Any contraindication for the ultrasound contrast agent including cardiac right to left shunt, pulmonary hypertension, uncontrolled hypertension, instable coronary disease

7. Has any medical condition or circumstance which would significantly decrease the chances of obtaining reliable data, achieving study objectives, or completing the study