Table 3 Univariate analyses of clinical parameters in mCRPC patients
Parameters | PSA PFS | OS | rPFS | |||
|---|---|---|---|---|---|---|
HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | |
Age (years) | 1.0 (0.9–1.0) | 0.1 | 1.00 (0.9–1.1) | 1.0 | 1.0 (0.9–1.0) | 0.06 |
PSA (μg/L) (> 10 vs ≤10) | 3.8 (0.9–16.2) | 0.035 | 26.5 (0.01–49,948.6) | 0.08 | 3.0 (0.7–12.7) | 0.09 |
Gleason Score (> 7 vs ≤7) | 0.8 (0.4–1.9) | 0.65 | 1.07 (0.3–3.83) | 0.92 | 0.9 (0.38–2.21) | 0.84 |
ALP (≤120 vs > 120 U/L) | 0.3 (0.1–0.7) | 0.01 | 0.2 (0–0.9) | 0.05 | 0.3 (0.09–0.66) | 0.01 |
Hb(g/L) | 1.0 (0.97–1.01) | 0.34 | 1.0 (0.90–0.99) | 0.029 | 1.0 (0.95–1.01) | 0.14 |
Alb(g/L) | 0.9 (0.8–1.0) | 0.15 | 0.8 (0.6–1.0) | 0.04 | 0.9 (0.8–1.0) | 0.05 |
Time from ADT to castration resistance (≤18 vs > 18 months) | 2.9 (1.2–7.1) | 0.02 | 11.2 (2.2–57.7) | 0.002 | 4.0 (1.5–10.7) | 0.004 |
ECOG PS | 2.9 (1.4–5.7) | 0.004 | 1.6 (0.6–4.2) | 0.34 | 3.6 (1.7–7.9) | 0.001 |