Ameliorative effects of rutin against cisplatin-induced reproductive toxicity in male rats

BMC Urology

Table 2 Effect of Rutin treatment against cisplatin induced DNA damage in adult male rats

Groups (n = 4)	Control	Cisplatin	Cisplatin + Rutin	Rutin
No.of Comets/120 Cells	27 ± 2.97	58 ± 3.91^a***	43 ± 1.10^ab*	29 ± 1.41^c*
Head length (μm)	158.71 ± 6.43	119.80 ± 3.87^a***	132.29 ± 2.37^a*	153.19 ± 7.42
Tail length (μm)	30.64 ± 1.91	53.25 ± 3.79^a***	40.25 ± 1.27^b*	33.74 ± 2.47^c*
DNA in head (%)	88.80 ± 1.59	71.52 ± 2.87^a***	74.37 ± 3.61^a*	84.22 ± 1.77
DNA in tail (%)	10.84 ± 3.20	24.57 ± 1.88^a***	22.51 ± 2.18^a*	12.65 ± 1.12^c*
Tail moment (μm)	3.60 ± 0.52	11.79 ± 1.59^a***	6.95 ± 1.76^ab*	3.84 ± 0.46^c*

Values are expressed as mean ± SEM *p < 0.05, **p < 0.01, ***p < 0.001, ^a = Value vs control, ^b = Value vs cisplatin, ^c = Value vs Cisplatin+Rutin

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