Ameliorative effects of rutin against cisplatin-induced reproductive toxicity in male rats

BMC Urology

Table 4 Effect of Rutin treatment against cisplatin induced alterations on germ cell stages in adult male rats

Groups (n = 4)	Spermatogonia	Primary Spermatocytes	Secondary Spermatocytes	Spermatids
Control	61.85 ± 1.14	45.05 ± 1.09	43.55 ± 1.01	91.25 ± 1.07
Cisplatin	47.8 ± 1.14^a***	34.35 ± 1.04^a***	29.9 ± 1.09^a***	68 ± 1.57^a***
Cisplatin+Rutin	55.85 ± 0.79^b***	39.1 ± 0.83^ab**	37.75 ± 0.81^a**b	73.75 ± 1.63^a***
Rutin	56.3 ± 1.40	40.3 ± 0.87^a**	35.3 ± 1.00	78.7 ± 2.19^a***

Values are expressed as mean ± SEM,*p < 0.05, **p < 0.01, ***p < 0.001, ^a = Value vs control, ^b = Value vs cisplatin, ^c = Value vs Cisplatin+Rutin

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