Variable | univariable cox regression analysis | multivariable cox regression analysis | ||||
---|---|---|---|---|---|---|
Hazard Ratio | 95% CI | p | Hazard Ratio | 95% CI | p | |
Age (continuous) | 1.024 | 0.986–1.064 | 0.216 | 1.013 | 0.971–1.056 | 0.556 |
Preoperative stage | 0.168 | 0.437 | ||||
Ta and Tis and T1 | – | referent | – | – | referent | – |
T2 | 2.011 | 0.630–6.419 | 0.238 | 0.983 | 0.236–4.102 | 0.981 |
T3 | 3.516 | 1.114–11.099 | 0.032 | 1.529 | 0.369–6.341 | 0.558 |
T4 | 1.509 | 0.167–13.609 | 0.714 | 0.286 | 0.025–3.296 | 0.316 |
Pathologic stage | 0.055 | 0.541 | ||||
Ta and Tis and T1 | – | referent | – | – | referent | – |
T2 | 2.904 | 0.792–10.654 | 0.108 | 2.003 | 0.460–8.721 | 0.355 |
T3 and T4 | 4.600 | 1.300–16.270 | 0.018 | 2.419 | 0.507–11.543 | 0.268 |
Pathologic nodal stage | ||||||
N0 | – | referent | – | – | Referent | – |
N+ | 4.372 | 1.883–10.150 | 0.001 | 4.067 | 1.424–11.610 | 0.009 |
No chemotherapy | – | referent | – | – | Referent | – |
Chemotherapy | 4.705 | 2.075–10.670 | <0.001 | 2.950 | 1.131–7.694 | 0.027 |
Location of the tumor | ||||||
other location | – | referent | – | – | Referent | – |
Posterior wall/trigone | 1.004 | 0.436–2.313 | 0.992 | 0.737 | 0.292–1.859 | 0.518 |
Negative margin | – | referent | – | – | Referent | – |
Positive margin | 3.369 | 0.778–14.584 | 0.104 | 1.500 | 0.253–8.904 | 0.656 |
No hysterectomy | – | referent | – | – | Referent | – |
Hysterectomy | 1.254 | 0.578–2.718 | 0.567 | 1.109 | 0.439–2.805 | 0.826 |