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Table 4 Hazard ratios of biochemical recurrence (BR) in multivariate model and BR-free survival following radical prostatectomy in men with fPSM or ePSM

From: Extent of positive surgical margins following radical prostatectomy: impact on biochemical recurrence with long-term follow-up

Study Year n fPSM no. (%) ePSM no. (%) Median follow-up, yr. HR for BR (95% CI) ePSM vs fPSM p value BR-free survival at 5 years for fPSM (%) BR-free survival at 5 years for ePSM (%) Including ≥pT3b, N+, neo or adjuvant treatment
Lake et al. [14] 2010 2022 344 (17.0) 99 (4.9) 4.1 NR 72 62 Yes
Lee e al [15] 2015 1733 114 (6.6) 359 (20.7) 4 NR 83 54 Yes
Sooriakumaran et al. [25] 2013 893 100 (11.2) 81 (9.1) 5 2.43 (1.14–5.18)
< 0.05
81 65 Yes
Stenphenson et al. [27] 2009 1501 983 (65.5) 518 (34.5) 7 1.3 (1.1–1.6)
0.004
63 43 No
May et al. [28] 2011 1036 122 (11.8) 145 (14.0) 4.3 1.0 (0.66–1.55)
0.96
49 51 No
Porpiglia et al. [29] a 2012 300 48 (16.0) 20 (6.7) 5.1 5.7 (1.5–2.17)
0.01
77 55 Yes
Ochiai et al. [30] 2007 117 81 (69.2) 32 (27.4) 3.6 NR 84 52 Yes
Van Oort et al. [31] 2010 174 NR NR 3.6 2.15 (1.12–4.2)
0.02
NR NR Yes
  1. In all studies, the cut-off for fPSM was the same as in our study (single margin ≤ 3 mm), except for Porpiglia et al.a (≤2.8 mm)
  2. NR not reported, HR hazard ratio, CI confidence interval, fPSM focal positive surgical margin, ePSM extensive positive surgical margin, PSA prostate-specific antigen