Skip to main content

Table 1 Details of survival, prognosis and other related factors of MFH cases from 2006-2017

From: A rare case of primary malignant fibrous histiocytoma: a sarcoma of the kidney

Author

Year

Management

Chemo/radio

Pathology

immune histochemistry

Survival (months/years)

Metastasis & recurrence

Gil-Julio H et al., [9]

2012

Partial nephrectomy

------------------

pleomorphic

MFH (with an abundant giant-cell population)

CD68 +

After a 41-month follow-up period, she was alive

During follow up period, there was no evidence of recurrence

Pathrose G et al., [16]

2015

Radical nephrectomy& splenectomy

---------

Inflammatory subtype of MFH (pleomorphic spindle cells, interspersed with foamy histiocytes)

CD68 +

anti α1 antichymotrysin+

-------------------------

-------------------------

Ghosh A et al., [22]

2008

Radical nephrectomy

-------------------

Inflammatory subtype of MFH (xanthoma cells with atypical histiocytes, mononuclear and multinu-Cleated giant cells)

Vimentin+

The patient died, 11 months after surgery

local recurrence, and pulmonary metastasis

Chen Y et al., [25]

2014

radical nephrectomy

The patient refused further treatment

MFH

Vimentin+, CD68 +

she remains alive, 78 months after first operation

9-month after surgery, a metastatic focus was found near to the abdominal aorta, however 12 and 18 months after first surgery, the metastases had disappeared (CT scan examination).

Gogus C et al., [26]

2013

Radical nephrectomy& resection of colon

Poly-chemotherapy (Adriblastina, Holoxan, Uromitexan, and radiotherapy)

MFH penetrated the capsule (Spindle-shaped fibroblastic cells in collagenous stroma)

CD10++, vimentin ++ and CD68++. α1-antitrypsin+ and α1-antichymotrypsin +

she died within the first postoperative year

Five months after operation, she was found with multiple metastases. recurrence and omental metastases were observed.

Bairwa S et al., [30]

2017

radical nephrectomy

chemotherapy

MFH (pleomorphic spindle and multinucleated polygonal cells with storiform pattern admixed with some inflammatory cells)

vimentin+

the patient died within 6 months due to recurrence.

There was evidence of recurrence (side of metastasis was not exactly mentioned).

Singh SK et al., [36]

2006

The tumors were found to be non-resectable, so biopsies only were taken.

----------------

Neutrophilic infiltrate, scattered spindle cells and foam cells

CD68+, CD34+

he died due to the disease within 1 month.

-----------------------------------------

Cormio L et al., [37]

2014

Radical nephrectomy

Adjuvant radiotherapy (50 Gy in 25 sessions)

MFH (pleomorphic, and multinucleated cells, admixed with inflammatory cells)

Vimentin+

five years after surgery, she was alive

no evidence of disease recurrence.

Hsiao PJ et al., [42]

2016

exploratory laparotomy (the tumor was not completely removed at first. 6 months later, whole tumor resected by En bloc method)

neo‑adjuvant chemotherapy with 4 cycles (mesna, doxorubicin, ifosfamide, dacarbazine).

MFH (spindle cells in a storiform pattern and polygonal or rounded cells)

vimentin+

>5 years without recurrence.

The patient survives without tumor recurrence.