From: A rare case of primary malignant fibrous histiocytoma: a sarcoma of the kidney
Author | Year | Management | Chemo/radio | Pathology | immune histochemistry | Survival (months/years) | Metastasis & recurrence |
---|---|---|---|---|---|---|---|
Gil-Julio H et al., [9] | 2012 | Partial nephrectomy | ------------------ | pleomorphic MFH (with an abundant giant-cell population) | CD68 + | After a 41-month follow-up period, she was alive | During follow up period, there was no evidence of recurrence |
Pathrose G et al., [16] | 2015 | Radical nephrectomy& splenectomy | --------- | Inflammatory subtype of MFH (pleomorphic spindle cells, interspersed with foamy histiocytes) | CD68 + anti α1 antichymotrysin+ | ------------------------- | ------------------------- |
Ghosh A et al., [22] | 2008 | Radical nephrectomy | ------------------- | Inflammatory subtype of MFH (xanthoma cells with atypical histiocytes, mononuclear and multinu-Cleated giant cells) | Vimentin+ | The patient died, 11 months after surgery | local recurrence, and pulmonary metastasis |
Chen Y et al., [25] | 2014 | radical nephrectomy | The patient refused further treatment | MFH | Vimentin+, CD68 + | she remains alive, 78 months after first operation | 9-month after surgery, a metastatic focus was found near to the abdominal aorta, however 12 and 18 months after first surgery, the metastases had disappeared (CT scan examination). |
Gogus C et al., [26] | 2013 | Radical nephrectomy& resection of colon | Poly-chemotherapy (Adriblastina, Holoxan, Uromitexan, and radiotherapy) | MFH penetrated the capsule (Spindle-shaped fibroblastic cells in collagenous stroma) | CD10++, vimentin ++ and CD68++. α1-antitrypsin+ and α1-antichymotrypsin + | she died within the first postoperative year | Five months after operation, she was found with multiple metastases. recurrence and omental metastases were observed. |
Bairwa S et al., [30] | 2017 | radical nephrectomy | chemotherapy | MFH (pleomorphic spindle and multinucleated polygonal cells with storiform pattern admixed with some inflammatory cells) | vimentin+ | the patient died within 6 months due to recurrence. | There was evidence of recurrence (side of metastasis was not exactly mentioned). |
Singh SK et al., [36] | 2006 | The tumors were found to be non-resectable, so biopsies only were taken. | ---------------- | Neutrophilic infiltrate, scattered spindle cells and foam cells | CD68+, CD34+ | he died due to the disease within 1 month. | ----------------------------------------- |
Cormio L et al., [37] | 2014 | Radical nephrectomy | Adjuvant radiotherapy (50 Gy in 25 sessions) | MFH (pleomorphic, and multinucleated cells, admixed with inflammatory cells) | Vimentin+ | five years after surgery, she was alive | no evidence of disease recurrence. |
Hsiao PJ et al., [42] | 2016 | exploratory laparotomy (the tumor was not completely removed at first. 6 months later, whole tumor resected by En bloc method) | neo‑adjuvant chemotherapy with 4 cycles (mesna, doxorubicin, ifosfamide, dacarbazine). | MFH (spindle cells in a storiform pattern and polygonal or rounded cells) | vimentin+ | >5 years without recurrence. | The patient survives without tumor recurrence. |