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Fig. 5 | BMC Urology

Fig. 5

From: Altered detrusor contractility and voiding patterns in mice lacking the mechanosensitive TREK-1 channel

Fig. 5

Effect of electric field stimulation and high potassium on WT and TREK-1 KO bladder detrusor strip contractile function. a Isolated BSM strips from TREK-1 KO mice showed significantly higher contractile force in response to EFS (80 V, 32 Hz, 1 ms duration). The left panel shows overlapped examples of raw traces from both groups. Middle panel represents the summary of PF normalized to the weight of tissue strips whereas right panel shows the integral force for both groups. b Effect of KCl stimulation on PF in WT (N = 17, n = 34) and TREK-1 KO (N = 17, n = 34) groups before and after pharmacological activation (by AA) and inhibition (by ML) of TREK-1 channels. Left panel represents raw traces of recordings. * - p ≤ 0.05 to WT group

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