Fig. 3

The results of Gene Set Enrichment Analysis (GSEA) in tumor tissue compared to normal tissue. Two collections of gene sets from Molecular Signatures Database (MSigDB) were analyzed: a) Hallmarks of well-defined biological states of processes (10/10 enriched signatures for tumor tissue are shown). b Gene Ontology database: biological processes (top 20/809 enriched signatures are shown). False discovery rate was set at a cut-off of 0.25; 1000 permutations were made for every analysis. Abbreviations: NES – normalized enrichment score (main metrics of GSEA); FDR – false discovery rate