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Fig. 3 | BMC Urology

Fig. 3

From: Long-term response of metastatic hereditary leiomyomatosis and renal cell carcinoma syndrome associated renal cell carcinoma to bevacizumab plus erlotinib after temsirolimus and axitinib treatment failures

Fig. 3

Gross and histologic characteristics of the primary tumor. a Nephrectomy specimen, the 11.8x7x7 cm sized well-demarcated, multilobulated mass in the right kidney had a whitish yellow, soft, friable papillary cut surface with renal vein thrombi (arrow). b Renal tumors exhibited infiltrative, tubulopapillary architectural growth intermixed with tumoral renal parenchyma (× 40). c Tumors were composed of large cells with abundant eosinophilic cytoplasm, large nuclei, and prominent inclusion-like eosinophilic nucleoli with perinuclear halos (× 400). d No expression of fumarate hydrate in tumor cells on immnohistochemical staining (× 200)

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