Fig. 3From: Long-term response of metastatic hereditary leiomyomatosis and renal cell carcinoma syndrome associated renal cell carcinoma to bevacizumab plus erlotinib after temsirolimus and axitinib treatment failuresGross and histologic characteristics of the primary tumor. a Nephrectomy specimen, the 11.8x7x7 cm sized well-demarcated, multilobulated mass in the right kidney had a whitish yellow, soft, friable papillary cut surface with renal vein thrombi (arrow). b Renal tumors exhibited infiltrative, tubulopapillary architectural growth intermixed with tumoral renal parenchyma (× 40). c Tumors were composed of large cells with abundant eosinophilic cytoplasm, large nuclei, and prominent inclusion-like eosinophilic nucleoli with perinuclear halos (× 400). d No expression of fumarate hydrate in tumor cells on immnohistochemical staining (× 200)Back to article page