Table 3 Subgroup analysis of CSS and OS by quality of the study, publication year, patient sample, number or type of intervention, and tumor size
Subgroup/co-variant | Coefficient | s.e. | P value | HR (95%CI); P value |
|---|---|---|---|---|
CSS | ||||
Quality | − 0.227 | 0.1580 | 0.195 | |
Publication year | 0.598 | 0.2929 | 0.096 | |
≤ 2015 | 0.44 (0.31–0.64); < 0.001 | |||
> 2015 | 0.76 (0.65–0.89); 0.03 | |||
Patient sample | −0.688 | 0.2539 | 0.030 | |
Cancer registry or single center | 0.78 (0.63–0.96); 0.02 | |||
Population based | 0.39 (0.26–0.60); < 0.001 | |||
Type of intervention | −0.014 | 0.2628 | 0.958 | |
PN | 0.67 (0.49–0.90); 0.008 | |||
TA | 0.68 (0.52–0.89); 0.005 | |||
Tumor size | −0.567 | 0.2342 | 0.046 | |
T1a | 0.68 (0.56–0.82); < 0.001 | |||
Not only T1a | 0.70 (0.36–1.38); 0.31 | |||
OS | ||||
Quality | −0.446 | 0.1986 | 0.066 | |
Publication year | 0.560 | 0.3845 | 0.196 | |
≤ 2015 | 0.39 (0.33–0.46); < 0.001 | |||
> 2015 | 0.93 (0.65–1.34); 0.70 | |||
Patient sample | −0.658 | 0.4973 | 0.234 | |
Cancer registry or single center | 0.68 (0.53–0.88); 0.004 | |||
Population based | 0.36 (0.30–0.44); < 0.001 | |||
Intervention | 0.625 | 0.2489 | 0.049 | |
PN | 0.40 (0.34–0.47); < 0.001 | |||
TA | 1.05 (0.62–1.80); 0.85 | |||
Tumor size | −0.681 | 0.3091 | 0.070 | |
T1a | 0.43 (0.36–0.51); < 0.001 | |||
Not only T1a | 0.58 (0.42–0.82); 0.002 | |||