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Table 3 Association between patient, disease and operative characteristics and pathological upgrading after RP

From: Pathological upgrading in prostate cancer treated with surgery in the United Kingdom: trends and risk factors from the British Association of Urological Surgeons Radical Prostatectomy Registry

Characteristic

No upgrade (n = 13,109)

Upgrade (n = 4489)

p-value

Age (years)

63.2 (6.56)

63.3 (6.44)

0.159

Preoperative PSA (ng/ml)

9.81 (7.93)

10.8 (8.94)

< 0.001

Preoperative biopsy ISUP Grade Group

< 0.001

 1

1550 (39.6%)

2364 (60.4%)

 

 2

6811 (81.8%)

1517 (18.2%)

 

 3

2572 (88.9%)

321 (11.1%)

 

 4

1213 (85.0%)

214 (15.0%)

 

 5

963 (93.0%)

73 (7.05%)

 

Preoperative clinical stage

< 0.001

 T1

3957 (72.8%)

1478 (27.2%)

 

 T2

6350 (76.4%)

1961 (23.6%)

 

 T3

2792 (72.7%)

1047 (27.3%)

 

 T4

10 (76.9%)

3 (23.1%)

 

Preoperative D’Amico risk group

< 0.001

 Low risk

782 (44.3%)

984 (55.7%)

 

 Intermediate risk

5307 (80.9%)

1256 (19.1%)

 

 High risk

7020 (75.7%)

2249 (24.3%)

 

Year of surgery

< 0.001

 2011

695 (69.4%)

306 (30.6%)

 

 2012

848 (73.2%)

311 (26.8%)

 

 2013

1602 (70.9%)

657 (29.1%)

 

 2014

2835 (74.9%)

948 (25.1%)

 

 2015

3420 (74.9%)

1146 (25.1%)

 

 2016

3709 (76.8%)

1121 (23.2%)

 

Region

< 0.001

 A

68 (86.1%)

11 (13.9%)

 

 B

544 (77.6%)

157 (22.4%)

 

 C

1239 (75.0%)

414 (25.0%)

 

 D

1643 (79.0%)

438 (21.0%)

 

 E

552 (78.2%)

154 (21.8%)

 

 F

1536 (73.7%)

548 (26.3%)

 

 G

1020 (77.6%)

295 (22.4%)

 

 H

18 (62.1%)

11 (37.9%)

 

 I

49 (73.1%)

18 (26.9%)

 

 J

1553 (74.2%)

540 (25.8%)

 

 K

1382 (73.3%)

503 (26.7%)

 

 L

1301 (74.9%)

435 (25.1%)

 

 M

505 (67.8%)

240 (32.2%)

 

 N

1246 (69.3%)

552 (30.7%)

 

 O

226 (69.8%)

98 (30.2%)

 

 P

227 (75.2%)

75 (24.8%)

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