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Table 3 Association between patient, disease and operative characteristics and pathological upgrading after RP

From: Pathological upgrading in prostate cancer treated with surgery in the United Kingdom: trends and risk factors from the British Association of Urological Surgeons Radical Prostatectomy Registry

Characteristic No upgrade (n = 13,109) Upgrade (n = 4489) p-value
Age (years) 63.2 (6.56) 63.3 (6.44) 0.159
Preoperative PSA (ng/ml) 9.81 (7.93) 10.8 (8.94) < 0.001
Preoperative biopsy ISUP Grade Group < 0.001
 1 1550 (39.6%) 2364 (60.4%)  
 2 6811 (81.8%) 1517 (18.2%)  
 3 2572 (88.9%) 321 (11.1%)  
 4 1213 (85.0%) 214 (15.0%)  
 5 963 (93.0%) 73 (7.05%)  
Preoperative clinical stage < 0.001
 T1 3957 (72.8%) 1478 (27.2%)  
 T2 6350 (76.4%) 1961 (23.6%)  
 T3 2792 (72.7%) 1047 (27.3%)  
 T4 10 (76.9%) 3 (23.1%)  
Preoperative D’Amico risk group < 0.001
 Low risk 782 (44.3%) 984 (55.7%)  
 Intermediate risk 5307 (80.9%) 1256 (19.1%)  
 High risk 7020 (75.7%) 2249 (24.3%)  
Year of surgery < 0.001
 2011 695 (69.4%) 306 (30.6%)  
 2012 848 (73.2%) 311 (26.8%)  
 2013 1602 (70.9%) 657 (29.1%)  
 2014 2835 (74.9%) 948 (25.1%)  
 2015 3420 (74.9%) 1146 (25.1%)  
 2016 3709 (76.8%) 1121 (23.2%)  
Region < 0.001
 A 68 (86.1%) 11 (13.9%)  
 B 544 (77.6%) 157 (22.4%)  
 C 1239 (75.0%) 414 (25.0%)  
 D 1643 (79.0%) 438 (21.0%)  
 E 552 (78.2%) 154 (21.8%)  
 F 1536 (73.7%) 548 (26.3%)  
 G 1020 (77.6%) 295 (22.4%)  
 H 18 (62.1%) 11 (37.9%)  
 I 49 (73.1%) 18 (26.9%)  
 J 1553 (74.2%) 540 (25.8%)  
 K 1382 (73.3%) 503 (26.7%)  
 L 1301 (74.9%) 435 (25.1%)  
 M 505 (67.8%) 240 (32.2%)  
 N 1246 (69.3%) 552 (30.7%)  
 O 226 (69.8%) 98 (30.2%)  
 P 227 (75.2%) 75 (24.8%)