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Table 3 Univariate and multivariate standard Cox proportional hazards analysis of variables associated with tumor recurrence, progression and treatment failure in all patients

From: Comparison of gemcitabine and anthracycline antibiotics in prevention of superficial bladder cancer recurrence

Variable

Univariate HR (95% CI)

P

Multivariate HR (95% CI)

p

Recurrence

 Gender

1.338 (0.817–2.191)

0.247

  

 Age

1.497 (0.658–3.403)

0.336

  

 Multifocality

1.526 (0.642–3.629)

0.339

  

 Size

1.869 (0.850–4.108)

0.120

2.668 (1.146–6.215)

0.023

 Grade

0.443 (0.190–1.033)

0.060

1.243 (0.232–6.664)

0.800

 Risk

  Lowa

  Immediate

1.934 (0.696–5.371)

0.206

2.762 (0.461–16.543)

0.266

  High

3.019 (1.186–7.685)

0.020

3.632 (0.535–24.633)

0.187

reTURBT

0.441 (0.182–1.068)

0.070

0.667 (0.134–3.313)

0.620

 Gemcitabine vs Epirubicin or Pirarubicin

0.159 (0.066–0.382)

0.000

0.179 (0.072–0.447)

< 0.001

Progression

 Gender

1.266 (0.583–2.747)

0.552

  

 Age

0.765 (0.221–2.644)

0.672

  

 Multifocality

4.063 (0.819–20.143)

0.086

4.168 (0.827–21.000)

0.084

 Size

2.188 (0.195–24.519)

0.525

  

 Grade

1.333 (0.376–4.727)

0.657

  

 Risk

  Lowa

  Immediate

0.993 (0.181–5.432)

0.993

  

  High

1.945 (0.486–7.780)

0.347

  

reTURBT

0.323 (0.068–1.521)

0.153

0.278 (0.055–1.394)

0.120

 Gemcitabine vs Epirubicin or Pirarubicin

0.110 (0.023–0.518)

0.005

0.155 (0.031–0.781)

0.024

Treatment failure

 Gender

0.447 (0.128–1.561)

0.207

  

 Age

2.094 (0.736–5.960)

0.166

2.244 (0.591–8.527)

0.235

 Multifocality

2.156 (0.739–6.290)

0.160

1.447 (0.479–4.368)

0.512

 Size

0.897 (0.314–2.562)

0.840

  

 Grade

1.485 (0.491–4.485)

0.484

  

 Risk

  Lowa

  Immediate

1.315 (0.443–3.906)

0.622

  

  High

0.455 (0.099–2.080)

0.310

  

reTURBT

1.429 (0.537–3.804)

0.475

  

 Gemcitabine vs Epirubicin or Pirarubicin

0.377 (0.140–1.018)

0.054

0.248 (0.074–0.830)

0.024

  1. aReferenced category. reTURBT, repeated transurethral resection of bladder tumor