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Table 1 Summary of the literature on postoperative bilateral adrenal hemorrhage since 2013

From: Bilateral adrenal hemorrhage after hip arthroplasty: an initially misdiagnosed case

No.

Year

Age

Gender

Procedure

DVT prophylaxis

POD

Symptoms

Lab. exams

Treatment

Outcome

Ref.

1

2013

52

F

Right hip arthroplasty

LMWH

9

Ap, hypotension, vomiting, weakness

Hyponatremia, hyperkalemia

Hydrocortisone fludrocortisone

Adrenal insufficiency, oral replacement

[9]

2

2014

67

M

Laparotomy, adhesiolysis

Not shown

4

Ap, confused, pyrexia

Hyponatraemia, hypocalcaemia

hypermagnesaemia

Hydrocortisone

Long-term fludrocortisone

[10]

3

2014

48

F

Right partial nephrectomy

LMWH (for PE)

6

Syncope, hypotension, lethargy, fever

Thrombocytopenia, hyponatremia

Hydrocortisone

Adrenal insufficiency, oral replacement

[11]

4

2015

45

F

Chole-cystectomy

LMWH

9

Ap, fever, nausea, vomiting

Hyponatremia, thrombocytosis, antiphospholipid antibodies(+)

Fludrocortisone

well

[6]

5

2015

65

F

Total knee

arthroplasty

LMWH

enoxaparin

8

Vague, epigastric pain, lethargy, fever, nausea

Hyponatremia, hypokalemia

Hydrocortisone

well

[12]

6

2015

75

M

Total hip replacement

Warfarin

14

Watery diarrhoea, vomiting, hypotension

Hyponatremia, hyperkalemia

Hydrocortisone

Adrenal insufficiency, oral replacement

[13]

7

2015

48

F

Total knee arthroplasty

Aspirin LMWH

8

Ap, fever, hypotension

Thrombocytopenia, heparin platelet factor 4 antibody(+)

Steroids

Well

[14]

8

2016

93

F

Hemi-colectomy

Not shown

4

Ap, hypotension, syncope

hyponatremia, hypokalemia, heparin platelet factor 4 antibody(+)

Hydrocortisone

Stable, lifelong steroids

[15]

9

2017

76

F

Pancreaticoduodenectomy

Not shown

5

Ap, hypotension, nausea, vomiting

Hemoglobin drop, hyponatremia, hyperkalemia

Hydrocortisone

well

[16]

10

2018

65

F

Colectomy

LMWH

4

Fever, fatigue, lethargy, hypotension

Hyponatremia, hyperkalemia

Steroids

well

[8]

11

2018

72

M

Total colectomy

LMWH

5

Anorexia, lethargy, hypotension, fever

Hyponatremia; anticardiolipin antibodies(+)

Hydrocortisone

well

[8]

12

2019

57

F

Left hip arthroplasty

LMWH enoxaparin

8

Ap, fever, nausea, vomiting, weakness

Hyponatremia, hypochloremia, metabolic acidosis

Oral predni-solone acetate

Adrenal insufficiency, oral replacement

Our case

  1. DVT Deep venous thrombosis, POD Postoperative day, Lab. Laboratory, LMWH Low-molecular-weight heparin, Ap Abdominal pain, PE Pulmonary embolism