Table 2 Candidate genes
GENE | MEDIAN RPKM in ccRCC (based on expression data from TCGA consortium, [31]) | FOLD DIFFERENCE, median rpkm in ccRCC vs. median rpkm in normal kidney (based on expression data from TCGA consortium, [31]) | RPKM DISTRIBUTION DISTANCE, 5th percentile ccRCC/ 95th percentile normal kidney (based on expression data from TCGA consortium, [31]) | BLOOD RPKM value of 95th percentile (based on GEO database [34]) | BLOOD RPKM value of 95th percentile (based on GTEx database [35]) |
|---|---|---|---|---|---|
NDUFA4L2 | 701 | 145 | 1.06 | 0.16 | 0.15 |
EGLN3 | 174 | 23.2 | 0.93 | 0.72 | 0.62 |
CA9 | 117 | 1218 | 3.74 | 1 | 0.13 |
CCND1 | 138 | 4.34 | 0.58 | 0.58 | 0.37 |
CAV2 | 110 | 3.98 | 0.69 | 0.43 | 0.43 |
ESM1 | 92.5 | 12.4 | 0.6 | 0.77 | 0.2 |
PPP1R3C | 20.1 | 3.66 | 0.54 | 0.03 | 0.67 |
STC2 | 19.1 | 22.3 | 1.33 | 0 | 0.07 |
NPTX2 | 18.4 | 150 | 1.48 | 0.07 | 0.13 |
ANGPT2 | 17.1 | 10.4 | 0.54 | 0.11 | 0.08 |
DGCR5 | 15.2 | 25.9 | 0.99 | 0.3 | 0.17 |
DOCK6 | 13.2 | 2.08 | 0.51 | 0.26 | 0.68 |
FABP6 | 11.9 | 91.3 | 1.18 | 0.62 | 0.85 |
TMEM133 | 8.9 | 2.67 | 0.52 | 0.60 | 0.24 |
LZTS1 | 8.81 | 5.54 | 0.52 | 0.26 | 0.25 |
COX4I2 | 6.85 | 4.37 | 0.52 | 0.06 | 0.15 |
KIAA1274 | 6.71 | 4.11 | 0.58 | 0.78 | 0.41 |
LPIN3 | 6.14 | 2.29 | 0.54 | 0.12 | 0.17 |
FKBP9L | 6.11 | 1.32 | 0.51 | 0.71 | 0.14 |
RAB42 | 5.90 | 5.47 | 1.02 | 0.17 | 0.49 |
MET | 112 | 2.08 | 0.36 | 0.07 | 0.1 |
CDK18 | 85.4 | 5.29 | 0.28 | 1.21 | 0.85 |
CP | 79.7 | 21.3 | 0.11 | 0.89 | 0.4 |
TMEM45A | 62.9 | 2.43 | 0.71 | 0.13 | 2.31 |
LOX | 51.0 | 10.8 | 0.22 | 0.22 | 0.29 |
GAL3ST1 | 49.4 | 8.14 | 0.3 | 0.15 | 0.11 |
CYP2J2 | 49 | 39.3 | 0.27 | 0.65 | 0.2 |
NOL3 | 44.1 | 10.6 | 1.36 | 1.98 | 2.47 |
FBXO17 | 38.7 | 2.77 | 0.5 | 2 | 0.12 |
FABP7 | 19.9 | 974 | 0.22 | 0 | 0.05 |
BARX2 | 19.1 | 6.01 | 0.27 | 0.42 | 0.04 |