Table 6 Summary of the published papers on neoadjuvant intra-arterial chemotherapy followed by radical cystectomy
Study | Year | Country | Type of study | Sample size (RC/total) | Chemotherapy regimen | No. of cycles | Interval to RC, (wks.) | Downstaging, (%), only RC | OS (only RC) |
|---|---|---|---|---|---|---|---|---|---|
Kanoh et al. [13] | 1983 | Japan | Retrospective | 7/13 | ADM | 2/wk. (≥3 wks) | 6.7 | 5 (71.4) | 2 died (14.6) |
Kamidono et al. [14] | 1984 | Japan | Retrospective | 11/11 | ADM, MMC | 1 | 4.2 | 7 (63.6) | 3 died (17.5) |
Maatman et al. [15] | 1986 | Italia | Prospective | 16/25 | CDDP, ADM | 1–4 | 4 | 4 (25) | 1 died (15.7) |
Kanoh et al. [16] | 1987 | Japan | Retrospective | 15/32 | ADM ± CDDP | 10–23 (17) | – | – | 1 died, 5-year OS 87.5% |
Kakizaki et al. [17] | 1987 | Japan | Retrospective | 29/29 | MMC, CPM, thio-TEPA, 5-FU, ADM, CDDP | 1 | 2 | – | – |
Jacobs et al. [18] | 1989 | USA | Retrospective | 16/30 | CDDP | 1 | 4 | 15 (93.8) | 3 N+ average 13 mo 8 N0 average 28 ± 8 mo |
Galetti et al. [19] | 1989 | USA | Phase II | 4/8(only IA) | CDDP | 1 | – | 3 (75) | 37mo (6–56) |
Arima et al. [20] | 1997 | Japan | Retrospective | 80/120 | ADM + CDDP | 1–4 | – | 75 (62.5) | – |
Miyata et al. [21] | 2015 | Japan | Retrospective | 17/50 | CDDP, ADM, EPI | 2 ± 0.2 | 4–8 | – | – |
Recent study | 2019 | China | Retrospective | 26/26 | GC | 1 | 4 | 17 (65.4) | 3 died (2 from cancer: 11 and 31mo) |