Table 2 Results of multinomial regression models for treatment approaches in patients with RCC. Two separate models are shown: one including all patients and the other including only the 6-month landmark analysis subgroup

Age (80 vs. 70)^*

Reference

0.46 (0.26–0.80)^**

0.70 (0.46–1.07)

0.39 (0.21–0.75)

Reference

0.58 (0.26–1.32)

0.77 (0.37–1.61)

0.40 (0.17–0.95)^**

Sex (male vs. female)

Reference

0.71 (0.47–1.08)

0.99 (0.69–1.42)

1.01 (0.62–1.64)

Reference

0.74 (0.40–1.34)

1.27 (0.72–2.23)

1.00 (0.53–1.89)

Race (white vs. other)

Reference

1.23 (0.71–2.14)

0.75 (0.50–1.12)

0.94 (0.53–1.67)

Reference

1.20 (0.55–2.58)

0.70 (0.37–1.32)

0.80 (0.38–1.70)

Metro/urban

Reference

0.89 (0.57–1.39)

1.03 (0.72–1.49)

0.57 (0.35–0.94)

Reference

0.97 (0.52–1.81)

1.61 (0.91–2.83)

0.68 (0.36–1.29)

Less urban/rural

Reference

1.09 (0.61–1.94)

0.84 (0.50–1.42)

0.54 (0.26–1.08)

Reference

1.32 (0.59–2.95)

1.04 (0.46–2.32)

0.51 (0.20–1.28)

Marital status (married vs. unmarried)

Reference

1.43 (0.94–2.18)

1.48 (1.04–2.13)

3.13 (1.92–5.11)

Reference

1.05 (0.58–1.91)

0.87 (0.50–1.53)

2.51 (1.31–4.80)

CCI (per 1-point increase)

Reference

0.77 (0.66–0.89)

0.86 (0.77–0.96)

0.82 (0.70–0.96)

Reference

0.89 (0.73–1.10)

1.04 (0.87–1.23)

0.92 (0.74–1.13)

Age (80 vs. 70)^*

2.19 (1.25–3.82)

Reference

1.54 (0.84–2.81)

0.86 (0.40–1.84)

1.72 (0.76–3.92)

Reference

1.32 (0.61–2.87)

0.68 (0.28–1.65)

Sex (male vs. female)

1.41 (0.92–2.15)

Reference

1.40 (0.88–2.22)

1.43 (0.83–2.46)

1.36 (0.75–2.48)

Reference

1.72 (0.97–3.05)

1.36 (0.73–2.53)

Race (white vs. other)

0.81 (0.47–1.41)

Reference

0.60 (0.34–1.08)

0.76 (0.38–1.53)

0.84 (0.39–1.81)

Reference

0.58 (0.28–1.19)

0.67 (0.30–1.49)

Metro/urban

1.12 (0.72–1.75)

Reference

1.16 (0.72–1.87)

0.64 (0.37–1.13)

1.03 (0.55–1.92)

Reference

1.65 (0.92–3.00)

0.70 (0.37–1.33)

Less urban/rural

0.92 (0.51–1.63)

Reference

0.77 (0.41–1.46)

0.49 (0.23–1.06)

0.75 (0.34–1.68)

Reference

0.78 (0.36–1.70)

0.38 (0.16–0.92)

Marital status (married vs. unmarried)

0.70 (0.46–1.06)

Reference

1.04 (0.66–1.64)

2.19 (1.26–3.80)

0.95 (0.52–1.72)

Reference

0.83 (0.47–1.46)

2.38 (1.26–4.50)

CCI (per 1-point increase)

1.30 (1.12–1.51)

Reference

1.12 (0.95–1.32)

1.07 (0.88–1.30)

1.12 (0.91–1.37)

Reference

1.16 (0.95–1.41)

1.02 (0.82–1.28)

Age (80 vs. 70)^*

1.42 (0.93–2.17)

0.65 (0.36–1.19)

Reference

0.56 (0.28–1.10)

1.30 (0.62–2.73)

0.76 (0.35–1.64)

Reference

0.52 (0.23–1.18)

Sex (male vs. female)

1.01 (0.70–1.44)

0.72 (0.45–1.13)

Reference

1.02 (0.61–1.70)

0.79 (0.45–1.39)

0.58 (0.33–1.03)

Reference

0.79 (0.43–1.46)

Race (white vs. other)

1.34 (0.89–2.01)

1.66 (0.93–2.96)

Reference

1.27 (0.70–2.29)

1.44 (0.75–2.73)

1.72 (0.84–3.51)

Reference

1.15 (0.58–2.31)

Metro/urban

0.97 (0.67–1.39)

0.86 (0.53–1.39)

Reference

0.56 (0.33–0.94)

0.62 (0.35–1.10)

0.60 (0.33–1.09)

Reference

0.42 (0.23–0.78)

Less urban/rural

1.19 (0.70–2.00)

1.30 (0.68–2.46)

Reference

0.64 (0.30–1.35)

0.96 (0.43–2.16)

1.28 (0.59–2.78)

Reference

0.49 (0.20–1.21)

Marital status (married vs. unmarried)

0.67 (0.47–0.96)

0.96 (0.61–1.52)

Reference

2.11 (1.25–3.55)

1.15 (0.65–2.02)

1.21 (0.69–2.14)

Reference

2.88 (1.54–5.39)

CCI (per 1-point increase)

1.16 (1.04–1.30)

0.89 (0.76–1.05)

Reference

0.96 (0.81–1.13)

0.96 (0.81–1.15)

0.86 (0.71–1.05)

Reference

0.88 (0.72–1.08)

Age (80 vs. 70) ^*

2.55 (1.34–4.85)

1.16 (0.54–2.50)

1.79 (0.91–3.53)

Reference

2.52 (1.05–6.02)

1.46 (0.61–3.53)

1.93 (0.85–4.40)

Reference

Sex (male vs. female)

0.99 (0.61–1.60)

0.70 (0.41–1.21)

0.98 (0.59–1.64)

Reference

1.00 (0.53–1.88)

0.74 (0.40–1.37)

1.26 (0.68–2.33)

Reference

Race (white vs. other)

1.06 (0.60–1.88)

1.31 (0.66–2.61)

0.79 (0.43–1.43)

Reference

1.24 (0.59–2.63)

1.49 (0.67–3.28)

0.87 (0.43–1.73)

Reference

Metro/urban

1.74 (1.06–2.86)

1.55 (0.88–2.73)

1.80 (1.07–3.04)

Reference

1.47 (0.77–2.81)

1.43 (0.75–2.72)

2.37 (1.28–4.38)

Reference

Less urban/rural

1.87 (0.92–3.78)

2.04 (0.94–4.43)

1.57 (0.74–3.35)

Reference

1.98 (0.78–4.99)

2.62 (1.09–6.30)

2.05 (0.83–5.09)

Reference

Marital status (married vs. unmarried)

0.32 (0.20–0.52)

0.46 (0.26–0.80)

0.47 (0.28–0.80)

Reference

0.40 (0.21–0.76)

0.42 (0.22–0.79)

0.35 (0.19–0.65)

Reference

CCI (per 1-point increase)

1.22 (1.04–1.42)

0.94 (0.77–1.13)

1.05 (0.88–1.24)

Reference

1.09 (0.89–1.34)

0.98 (0.78–1.22)

1.13 (0.93–1.38)

Reference