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Table 2 Results of multinomial regression models for treatment approaches in patients with RCC. Two separate models are shown: one including all patients and the other including only the 6-month landmark analysis subgroup

From: Determinants of treatment in patients with stage IV renal cell carcinoma

 All patients w/ RCCPatients w/ RCC in the 6-month landmark analysis
 No treatmentSurgery onlyST onlySurgery + STNo treatmentSurgery onlyST onlySurgery + ST
VariableOR (95% CI)OR (95% CI)OR (95% CI)OR (95% CI)OR (95% CI)OR (95% CI)OR (95% CI)OR (95% CI)
No Treatment as Reference
Age (80 vs. 70)*Reference0.46 (0.26–0.80)**0.70 (0.46–1.07)0.39 (0.21–0.75)Reference0.58 (0.26–1.32)0.77 (0.37–1.61)0.40 (0.17–0.95)**
Sex (male vs. female)Reference0.71 (0.47–1.08)0.99 (0.69–1.42)1.01 (0.62–1.64)Reference0.74 (0.40–1.34)1.27 (0.72–2.23)1.00 (0.53–1.89)
Race (white vs. other)Reference1.23 (0.71–2.14)0.75 (0.50–1.12)0.94 (0.53–1.67)Reference1.20 (0.55–2.58)0.70 (0.37–1.32)0.80 (0.38–1.70)
Urban/rural code (ref: big metro)       
Metro/urbanReference0.89 (0.57–1.39)1.03 (0.72–1.49)0.57 (0.35–0.94)Reference0.97 (0.52–1.81)1.61 (0.91–2.83)0.68 (0.36–1.29)
Less urban/ruralReference1.09 (0.61–1.94)0.84 (0.50–1.42)0.54 (0.26–1.08)Reference1.32 (0.59–2.95)1.04 (0.46–2.32)0.51 (0.20–1.28)
Marital status (married vs. unmarried)Reference1.43 (0.94–2.18)1.48 (1.04–2.13)3.13 (1.92–5.11)Reference1.05 (0.58–1.91)0.87 (0.50–1.53)2.51 (1.31–4.80)
CCI (per 1-point increase)Reference0.77 (0.66–0.89)0.86 (0.77–0.96)0.82 (0.70–0.96)Reference0.89 (0.73–1.10)1.04 (0.87–1.23)0.92 (0.74–1.13)
Surgery only as Reference
Age (80 vs. 70)*2.19 (1.25–3.82)Reference1.54 (0.84–2.81)0.86 (0.40–1.84)1.72 (0.76–3.92)Reference1.32 (0.61–2.87)0.68 (0.28–1.65)
Sex (male vs. female)1.41 (0.92–2.15)Reference1.40 (0.88–2.22)1.43 (0.83–2.46)1.36 (0.75–2.48)Reference1.72 (0.97–3.05)1.36 (0.73–2.53)
Race (white vs. other)0.81 (0.47–1.41)Reference0.60 (0.34–1.08)0.76 (0.38–1.53)0.84 (0.39–1.81)Reference0.58 (0.28–1.19)0.67 (0.30–1.49)
Urban/rural code (ref: big metro)       
Metro/urban1.12 (0.72–1.75)Reference1.16 (0.72–1.87)0.64 (0.37–1.13)1.03 (0.55–1.92)Reference1.65 (0.92–3.00)0.70 (0.37–1.33)
Less urban/rural0.92 (0.51–1.63)Reference0.77 (0.41–1.46)0.49 (0.23–1.06)0.75 (0.34–1.68)Reference0.78 (0.36–1.70)0.38 (0.16–0.92)
Marital status (married vs. unmarried)0.70 (0.46–1.06)Reference1.04 (0.66–1.64)2.19 (1.26–3.80)0.95 (0.52–1.72)Reference0.83 (0.47–1.46)2.38 (1.26–4.50)
CCI (per 1-point increase)1.30 (1.12–1.51)Reference1.12 (0.95–1.32)1.07 (0.88–1.30)1.12 (0.91–1.37)Reference1.16 (0.95–1.41)1.02 (0.82–1.28)
ST only as Reference
Age (80 vs. 70)*1.42 (0.93–2.17)0.65 (0.36–1.19)Reference0.56 (0.28–1.10)1.30 (0.62–2.73)0.76 (0.35–1.64)Reference0.52 (0.23–1.18)
Sex (male vs. female)1.01 (0.70–1.44)0.72 (0.45–1.13)Reference1.02 (0.61–1.70)0.79 (0.45–1.39)0.58 (0.33–1.03)Reference0.79 (0.43–1.46)
Race (white vs. other)1.34 (0.89–2.01)1.66 (0.93–2.96)Reference1.27 (0.70–2.29)1.44 (0.75–2.73)1.72 (0.84–3.51)Reference1.15 (0.58–2.31)
Urban/rural code (ref: big metro)       
Metro/urban0.97 (0.67–1.39)0.86 (0.53–1.39)Reference0.56 (0.33–0.94)0.62 (0.35–1.10)0.60 (0.33–1.09)Reference0.42 (0.23–0.78)
Less urban/rural1.19 (0.70–2.00)1.30 (0.68–2.46)Reference0.64 (0.30–1.35)0.96 (0.43–2.16)1.28 (0.59–2.78)Reference0.49 (0.20–1.21)
Marital status (married vs. unmarried)0.67 (0.47–0.96)0.96 (0.61–1.52)Reference2.11 (1.25–3.55)1.15 (0.65–2.02)1.21 (0.69–2.14)Reference2.88 (1.54–5.39)
CCI (per 1-point increase)1.16 (1.04–1.30)0.89 (0.76–1.05)Reference0.96 (0.81–1.13)0.96 (0.81–1.15)0.86 (0.71–1.05)Reference0.88 (0.72–1.08)
Surgery + ST as Reference
Age (80 vs. 70) *2.55 (1.34–4.85)1.16 (0.54–2.50)1.79 (0.91–3.53)Reference2.52 (1.05–6.02)1.46 (0.61–3.53)1.93 (0.85–4.40)Reference
Sex (male vs. female)0.99 (0.61–1.60)0.70 (0.41–1.21)0.98 (0.59–1.64)Reference1.00 (0.53–1.88)0.74 (0.40–1.37)1.26 (0.68–2.33)Reference
Race (white vs. other)1.06 (0.60–1.88)1.31 (0.66–2.61)0.79 (0.43–1.43)Reference1.24 (0.59–2.63)1.49 (0.67–3.28)0.87 (0.43–1.73)Reference
Urban/rural code (ref: big metro)       
Metro/urban1.74 (1.06–2.86)1.55 (0.88–2.73)1.80 (1.07–3.04)Reference1.47 (0.77–2.81)1.43 (0.75–2.72)2.37 (1.28–4.38)Reference
Less urban/rural1.87 (0.92–3.78)2.04 (0.94–4.43)1.57 (0.74–3.35)Reference1.98 (0.78–4.99)2.62 (1.09–6.30)2.05 (0.83–5.09)Reference
Marital status (married vs. unmarried)0.32 (0.20–0.52)0.46 (0.26–0.80)0.47 (0.28–0.80)Reference0.40 (0.21–0.76)0.42 (0.22–0.79)0.35 (0.19–0.65)Reference
CCI (per 1-point increase)1.22 (1.04–1.42)0.94 (0.77–1.13)1.05 (0.88–1.24)Reference1.09 (0.89–1.34)0.98 (0.78–1.22)1.13 (0.93–1.38)Reference
  1. *Odds ratio shown for 75th vs 25th percentile because age was modeled non-linearly
  2. **Odds ratios and confidence intervals shown in bold are significant at the 5% level
  3. RCC Renal Cell Carcinoma, CCI Charlson Comorbidity Index