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Table 3 Expression of target proteins in the epithelial cells of the prostate tissue

From: Early upregulation of AR and steroidogenesis enzyme expression after 3 months of androgen-deprivation therapy

Expressions of proteins

H-score cut-offa

Upregulated cancer tissues

Primary PCa

(n = 7)

ADT-PCa

(n = 10)

≤ 12 months (n = 4)

> 12 months (n = 6)

n

%

n

%

Compared to primary PCab

n

%

Compared to primary PCab

AR

57%

1

14

2

50

0.2

6

100

< 0.01*

AKR1C3

39%

2

29

0

0

0.23

1

17

0.61

SRD5A1

41%

5

71

2

50

0.47

4

67

0.85

SRD5A2

85%

3

43

2

50

0.81

3

50

0.79

SRD5A3

41%

7

100

1

25

< 0.01*

3

50

0.03*

  1. a H-Score cut-off was measured from mean H-score of BPH group (n = 6) as mentioned in the method, to determine upregulation of protein expressions in malignant tissues (Primary PCa and ADT ≤ 12 months and > 12 months)
  2. b Statistical significance was measured for p-value by comparing the H score of ADT ≤ 12 months and > 12 months with Primary PCa using Pearson Chi Square
  3. *P-value < 0.05 is significant
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BMC Urology

ISSN: 1471-2490

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