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Table 4 ADT-treated prostate cancer patients characteristics and clinical and pathological parameters

From: Early upregulation of AR and steroidogenesis enzyme expression after 3 months of androgen-deprivation therapy

Characteristics

AR

SRD5A1

SRD5A2

SRD5A3

ADT < 12 Months

P-Valueb

ADT < 12 Months

P-Valueb

ADT < 12 Months

P-Valueb

ADT < 12 Months

P-Valueb

High

(n = 2)

No

(n = 2)

High

(n = 2)

No

(n = 2)

High

(n = 2)

No

(n = 2)

High

(n = 1)

No

(n = 3)

Age

59.5 ± 0.7

58 ± 5.6

0.75

56.5 ± 3.5

61 ± 1.4

1

56.5 ± 3.5

61 ± 1.4

1

54

60.3 ± 1.5

0.07

T Stages

  

0.05

  

0.32

  

0.32

  

0.25

 1

          

 2

100%

 

50%

50%

 

50%

50%%

 

67%

 

 3

 

 

 

 

 4

100%

 

50%

50%

 

50%

50%

 

100%

33%

 

Gleason scorea

  

0.25

  

0.25

  

0.25

  

0.50

  < 7

50%

 

50%

 

50%

 

33%

 

 08–10

50%

100%

 

100%

50%

 

100%

50%

 

100%

67%

 

PSA levela

160.6 (17.9–303.3)

20.2 (10.1–30.4)

0.19

156.7 (10.1–303.3)

22.3 (17.9–30.4)

1

156.7 (10.1–303.3)

22.3 (17.9–30.4)

1

10.1

30.4 (17.9–303.3)

0.5

ADT Type

  

  

  

  

 Orchyde

2

 

1

1

 

1

1

 

1

 

 LHRH agonist + antiandrogen

            

2

 

1

1

 

1

1

 

1

2

 

ADT Treatment Duration

5 (3–7)

6 (3–9)

8 (7–9)

3

8 (7–9)

3

9

3 (3–7)

  1. + is upregulated protein expression group; − is downregulated protein expression group
  2. a Age is presented in mean ± SD; PSA level and prostate volume are presented in median (min-max)
  3. b Statistical significance was measured by comparing the clinical parameters of upregulated and non-upregulated ADT-PCa samples using Independent T test for Age; Pearson chi square test for Gleason score; Mann-Whitney test for T-stages and PSA level
  4. *P-value < 0.05 is significant