Table 1 Literature review of Posterior Tibial Nerve Stimulation in Multiple Sclerosis

Fjorback [1]

‘07

8

UDS: DO and MCC < 300 mL

n/a

• PTNS unable to suppress detrusor contraction.

• No reduction of urgency

• No difference in peak detrusor pressure

• Median volume at first contraction was 36% higher with stimulation. (p = 0.0078)

Kabay [2]

‘08

29

storage symptoms

n/a

• Mean volume first involuntary contraction increased from 183 to 230 mL. (p < 0.001)

• Mean maximum cystometric capacity increased from 193 to 286 mL. (p < 0.001)

Kabay [3]

‘09

19

LUTS

3

• Complete Response rates > 50% improvement: urgency (33%), incontinence (40%), frequency (58%), nocturia (75%), pad test (90%) of patients

• Partial Response between 25 and 50% improvement:urgency (53%), incontinence (50%), frequency (26%), nocturia (25%), pad test (10%) of patients

• UDS response: DSD resolved in 3/5, significant improvement after PTNS in first involuntary detrusor contraction volume, MCC, Qmax, PVR (p < 0.05)

de Seze [4]**

‘11

70

refractory OAB symptoms

3

• 30d: 51% resolution of severe urgency, 67% reduction in frequency by 3 episodes/day

• 90d: improvement in 83.3% of patients in 3 day bladder diary, MHU or warning time

Gobbi [5]

‘11

18

refractory LUTS

3

• Improved frequency, nocturia, Increased voided volume,

• PPBC decreased by 3 points (p = 0.003), PPIUS decreased by 2 points (p = 0.005), UB-VAS decreased by 4 cm (p = 0.005), improvement in KHQ (p < 0.05)

Zecca [6]

‘14

initial: 83

Maint: 74

refractory LUTS, UDS with DO, UAB or DSD

24

• 60% (44/74) required maintenance every 2 weeks, 4% required maintenance every week, mean treatment was: 1.79 sessions/patient/month

• 82% of patients reported treatment satisfaction on TS-VAS, GRA, and PPBC at 24 months

Zecca [7]

‘14

83

refractory LUTS, UDS with Dom UAB or DSD

3

• Sensory response: 64%, Motor response: 6%, Sensory-Motor: 30%;

Sensory response with or without motor response was associated with better outcome than motor alone (p < 0.001)

Canbaz- Kabay [23]

‘17

initial: 29

Maint: 21

refractory OAB

12

• Improvement in frequency, nocturia, urgency (all p < 0.001) and voided volume improved mean 72 cc (p < 0.05).

• Change from baseline on the ICIQ-SF, OABv8 and OAB-q: decreased symptom severity and health related quality of life (P < 0.001)