From: Anti-TNF agents and potential effects on male fertility: are men being counseled?
Anti-TNF agent (Generic / Brand name) | Prescribing information |
---|---|
Adalimumab / Humira© | “Long-term animal studies of HUMIRA have not been conducted to evaluate the carcinogenic potential or its effect on fertility” [16]. |
Infliximab / Remicade© | “It is not known whether infliximab can impair fertility in humans” [17]. |
Etanercept / Enbrel© | “Long-term animal studies have not been conducted to evaluate the carcinogenic potential of etanercept or its effect on fertility” [18]. |
Golimumab / Simponi© | “A fertility study conducted in mice using an analogous anti-mouse TNFα antibody showed no impairment to fertility” [19]. |
Certolizumab / Cimzia© | “The cTN3 PF (TNFα pegylated Fab fragment) had no effects on the fertility and general reproductive performance of male and female rats at intravenous doses up 100 mg/kg, administered twice weekly” [20]. |