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Fig. 4 | BMC Urology

Fig. 4

From: LncRNA PLAC2 upregulates miR-663 to downregulate TGF-β1 and suppress bladder cancer cell migration and invasion

Fig. 4

A novel PLAC2/miR-663/TGF-β1 pathway was characterized. RT-qPCR results showed the altered expression of PLAC2, miR-663 and TGF-β1 at 24 h after transfections (a). Overexpression of PLAC2 resulted in upregulation of miR-663, while overexpression of miR-663 resulted in no significantly changed expression levels of PLAC2 (b). In addition, overexpression of PLAC2 and miR-663 resulted in the downregulation of TGF-β1, while miR-663 inhibitor attenuated the effects of PLAC2 overexpression (c). Moreover, overexpression of TGF-β1 did not significantly affect the expression of PLAC2 and miR-663 (d) (*, p < 0.05)

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