Skip to main content

Table 2 Patients with non-response

From: Can clinical and urodynamic parameters predict the occurrence of neutralizing antibodies in therapy failure of intradetrusor onabotulinumtoxin A injections in patients with spinal cord injury?

Patients with Non-Response

n = 69

Primary Non-Response (%)

6 (9)

Secondary Non-Response n (%)

63 (91)

Antibody high positive n (%)

14 (20)

Antibody positive n (%)

14 (20)

Antibody borderline n (%)

5 (8)

Antibody negative n (%)

36 (52)

Age at Non-Response (mean ± SD; range), years

44.91 ± 14.75; 15–86

Time from SCI/D onset to first BoNT-A (median; 25%/75%; range), years

6.57; 2.66/10.84; 0–34

Time from first BoNT-A injection to Non-Response (median; 25%/75%; range), years

4.91; 2.94/7.26; 0–14

Number of BoNT-A injections (median; 25%/75%; range)

8; 4/11; 1–24

Time interval between BoNT-A injections (median; 25%/75%; range), month

7.85; 6.4/8.97; 1–18

  1. (SCI/D Spinal cord injury/disease, BoNT-A botulinum neurotoxin A)