Table 1 Cox proportional hazards regression for RFS

Age

0.86

0.59

–

1.25

0.415

0.94

0.84

–

1.06

0.306

Sex

1.94

1.14

–

3.30

0.014*

1.66

0.71

–

3.88

0.245

4.13

0.98

–

17.44

0.054

Smoking

1.34

0.91

–

1.96

0.136

0.84

0.46

–

1.52

0.558

3.438

0.311

–

38.06

0.314

BMI > 24 kg/m²

1.1

0.75

–

1.62

0.610

1.61

0.65

–

3.98

0.301

Hypertension

0.74

0.51

–

1.08

0.113

1.12

0.60

–

2.06

0.726

0.67

0.25

–

1.77

0.418

Cre > 1.5 mg/dL

1.03

0.60

–

1.77

0.921

1.04

0.42

–

2.56

0.936

Dialysis

0.88

0.28

–

2.78

0.831

1.57

0.21

–

11.7

0.658

History of other cancers

0.71

0.36

–

1.41

0.335

0.63

0.15

–

2.69

0.536

cT1

2.14

1.47

–

3.12

< 0.001*

2.05

1.06

–

3.97

0.034*

1.83

0.87

–

3.86

0.112

CIS

1.58

1.03

–

2.41

0.036*

0.69

0.34

–

1.39

0.297

1.34

0.6

–

2.96

0.476

High grade

1.72

1.14

–

2.58

0.010*

0.85

0.43

–

1.68

0.643

1.45

0.61

–

3.42

0.400

Tumor number ≥ 3

2.49

1.58

–

3.94

< 0.001*

3.46

1.90

–

6.33

< 0.001*

0.99

0.41

–

2.41

0.982

Tumor size ≥3 cm

1.94

1.12

–

3.36

0.018*

1.90

1.05

–

3.42

0.033*

1.94

0.64

–

5.83

0.239

Intravesical therapy

0.97

0.36

–

2.64

0.958

21.8

< 0.01

–

>  11.00

0.790

DM

1.3

0.85

–

2.00

0.229

1.11

0.57

–

2.19

0.755

Urine sugar ≥100

1.86

0.87

–

3.97

0.108

HbA1c ≥7

3.64

1.14

–

11.65

0.029*

Metformin

1.36

0.60

–

3.10

0.460

TZD

0.26

0.04

–

1.90

0.184