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Table 2 Compare of clinicopathologic features and mutational profile by the presence of metastasis in clear cell RCC

From: Sharing the initial experience of pan-cancer panel analysis in high-risk renal cell carcinoma in the Korean population

  Localized
N = 12
Metastatic
N = 8
p-value
Age 61.4 ± 12.7 66.9 ± 8.6 0.303
Sex – male (%) 8 (66.7%) 5 (62.5%) 1.000
BMI (kg/m2) 25.7 ± 4.3 23.8 ± 6.3 0.439
DM 8 (66.7%) 6 (75.0%) 1.000
HTN 5 (41.7%) 3 (37.5%) 1.000
Mass size (cm) 5.8 ± 2.0 8.8 ± 2.4 0.008
Pathologic T stage – N (%)    0.071
  < T2 0 (0%) 2 (25.0%)  
T3 12 (100%) 5 (62.5%)  
T4 0 (0%) 1 (12.55)  
Tumor thrombus level– N (%)    0.225
Level 0 10 (83.3%) 5 (62.5%)  
Level 1 1 (8.3%) 3 (37.5%)  
Level 2 1 (8.3%) 0 (0%)  
Fuhrman grade    0.400‡
3 12 (100%) 4 (87.5%)  
4 0 (0%) 1 (12.5%)  
Lymphovascular invasion 2 (16.7%) 4 (50.0%) 0.161‡
Mutation Counts 7.0 ± 3.2 7.1 ± 2.9 0.930
VHL 9 (75.0%) 5 (62.5%) 0.642‡
PBRM1 2 (16.7%) 5 (62.5%) 0.062‡
NOTCH4 4 (33.3%) 1 (12.5%) 0.603‡
KMT2D 1 (8.3%) 1 (12.5%) 1.000‡
NOTCH3 2 (16.7%) 1 (12.5%) 1.000‡
TSC1 3 (25.0%) 1 (12.5%) 0.619
BAP1 5 (41.7%) 2 (25.0%) 0.642‡
BRCA2 2 (16.7%) 0 (0%) 0.495‡
SETD2 0 (0%) 1 (12.5%) 0.400‡
  1. for Pearson Chi-square, ‡ for Fisher’s Exact Test