Fig. 2

Effects of ZD7288 on the threshold value and number of action potentials of the medium-size DRG cells in OAB and sham-intervention rats. The threshold value and number of induced action potentials (AP) of medium-size DRG cells in the rat model of OAB and the effect of ZD7288 on both parameters were investigated. a:a shows the diagram of the original action potentials produced by the medium-size DRG cells, b shows the square wave used to induce the APs (starting from − 100 pA, increasing in steps of 10 pA); b: the threshold intensity of the cells in the OAB group was significantly decreased, and was significantly increased by 2 μM ZD7288; c: a shows the original diagram of the medium-size DRG cells’ action potential, b shows the 500 pA square wave used to elicit the action potentials; d: statistical analysis of the number of APs revealed a significant increase in the OAB group, which was significantly decreased by ZD7288 (*p < 0.05, ** p < 0.01, sham vs OAB group; ^#p < 0.05, OAB vs OAB + ZD7288 group; sham n = 24, sham+ZD7288 n = 24, OAB n = 19, OAB + ZD7288 n = 19)