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Fig. 3 | BMC Urology

Fig. 3

From: Hyperpolarization-activated cation currents in medium-size dorsal root ganglion cells are involved in overactive bladder syndrome in rats

Fig. 3

Effects of ZD7288 on the τ value of the medium-size cells in the L6 DRG of the OAB and sham-intervention rats. The τ value (time constant of slow depolarizing) of the DRG medium-size cells in the DRG of the OAB model rats was investigated, along with the effect of ZD7288 on this parameter. a: Square-wave stimulation of DRG medium-size cells under current-clamp conditions (800 pA, 60 ms, first row). ZD7288 significantly increased the τ value in the OAB model, whereas saline did not have an effect. b: Change of the τ value. The τ value was significantly decreased in the OAB rats, and ZD7288 was able to significantly increase it in both OAB and sham groups ($$p < 0.01, sham vs sham+ZD7288 group; **p < 0.01, sham vs OAB group; ##p < 0.01, OAB vs OAB + ZD7288 group; sham n = 12, sham+ZD7288 n = 12, OAB n = 13, OAB + ZD7288 n = 13)

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BMC Urology

ISSN: 1471-2490

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