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Table 2 Urinary bladder and voiding parameters, determined for each group of animals after intrathecal pharmaceutical administration for 7 days

From: Hyperpolarization-activated cation currents in medium-size dorsal root ganglion cells are involved in overactive bladder syndrome in rats

Parameter

Sham intervention

OAB

OAB + saline

OAB + ZD7288

Micturition Interval (Sec)

75.23 ± 5.71

32.85 ± 4.32**

33.45 ± 3.78

48.18 ± 6.58##

Micturition Volume (ml)

0.63 ± 0.42

0.21 ± 0.05**

0.34 ± 0.24

0.58 ± 0.32##

Micturition Time (s)

10.38 ± 0.74

12.65 ± 1.31*

13.02 ± 1.54

10.54 ± 1.53#

Difference between the Maximal and Basal Micturition Pressures (cmH2O)

54.35 ± 4.67

52.28 ± 7.49

51.76 ± 6.98

49.53 ± 4.87

Difference between the Threshold Pressure and Basal Pressure (cmH2O)

12.86 ± 1.08

9.59 ± 6.75

9.78 ± 7.31

8.87 ± 7.21

n

8

11

11

11

  1. OAB Overactive bladder syndrome group; OAB + saline: OAB group treated with saline; OAB + ZD7288: OAB group treated with ZD7288; *p < 0.05, **p < 0.01, OAB group compared to the sham-intervention group; #p < 0.05, ##p < 0.01, OAB group compared to the OAB + ZD7288 group (one-way ANOVA)