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Table 2 Univariable and multivariable logistic regression model of preoperative variables predicting pathological Gleason score ≥ 7

From: Preoperative prostate health index predicts adverse pathology and Gleason score upgrading after radical prostatectomy for prostate cancer

Variables Univariable analysis Multivariable analysis
OR (95% CI) p value Base model
OR (95% CI)
p value Base model + PHI
OR (95% CI)
p value
Age 1.02 (0.99–1.06) 0.1462 1.02 (0.99–1.05) 0.1660 1.02 (0.99–1.06) 0.1437
DRE 1.62 (1.01–2.60) 0.0395 1.71 (1.06–2.76) 0.0261 1.63 (1.00–2.65) 0.0440
PSA 1.07 (1.02–1.12) 0.0025 1.08 (1.03–1.14) 0.0013 1.05 (0.99–1.09) 0.0531
fPSA 0.98 (0.94–1.03) 0.4477 0.92 (0.82–1.02) 0.1146 0.96 (0.89–1.04) 0.2925
p2PSA 1.01 (0.99–1.02) 0.1212     
%p2PSA 1.03 (1.01–1.06) 0.0155     
PHI 1.02 (1.01–1.03) < 0.0001    1.02 (0197–1.03) 0.0015
  1. DRE digital rectal examination, PSA prostate specific antigen, fPSA free PSA, p2PSA [−2]proPSA, %p2PSA 2pSA/fPSA ratio, PHI Prostate Health Index, OR Odds ratio, CI confidence interval