Fig. 2

Histopathological classification of tumour and tumour stroma zones identifies initial acinar adenocarcinoma and progression to small cell carcinoma. (A) Overview of H&E stained sections used for histopathological and molecular analysis. Tissue zones comprising (i) tumour, (ii) tumour stroma, and (iii) mixed are indicated. Scale bar indicates 2 mm. b High magnification H&E stains of tumour stroma (one zone) and tumour (three zones) at each tissue collection timepoint. Scale bar indicates 100 µm