Fig. 5

Signature analysis uncovers aggressive SCPC and NEPC genetic profiles in recurrence. a Normalised expression heatmaps and hierarchical clustering of transcriptomic and proteomic changes in four biopsies. b Venn analysis of overlap in most increased (orange) and decreased (blue) molecules between transcriptomic and proteomic analysis. Common genes are listed below. c Normalised transcriptomic expression heatmap of commonly dysregulated genomic lesions in NEPC. (D-G) GSEA comparison transcriptomic changes in recurrence compared to diagnostic biopsy for published prostate cancer gene signatures of d prototypical SCPC, e atypical SCPC, f up- and down-regulated in SCPC versus AdPC and g up- and down-regulated in NEPC versus AdPC. SCPC: small cell prostate cancer, AdPC: prostate adenocarcinoma, NEPC: neuroendocrine prostate cancer, FDR: false discovery rate, NES: normalised enrichment score