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Table 2 Association of known RCC germline variants with RCC subtypes. Subtypes were defined molecularly based on individual acquired alterations, by mRNA molecular subtype (ccA/ccB) or clinically (Mayo SSIGN score).

From: 8q24 clear cell renal cell carcinoma germline variant is associated with VHL mutation status and clinical aggressiveness

RS ID Chrom REF ALT OR.bap1 P.bap1 OR.pbrm1 P.pbrm1 OR.setd2 P.setd2 OR.vhl P.vhl OR.ccAccB P.ccAccB OR.SSIGNcat P.SSIGNcat
rs4381241 1 T C 0.92 0.74 0.92 0.59 0.94 0.77 0.92 0.59 0.95 0.72 1.10 0.61
rs7579899 2 A G 0.95 0.85 1.02 0.92 1.87 0.012 0.99 0.93 1.12 0.45 0.95 0.79
rs12105918 2 T C 2.05 0.05 0.66 0.16 0.58 0.23 1.36 0.23 0.86 0.57 0.84 0.58
rs67311347 3 G A 1.29 0.33 1.00 0.98 1.04 0.88 1.17 0.33 1.02 0.90 0.89 0.57
rs10936602 3 T C 1.22 0.49 0.77 0.18 0.73 0.26 1.11 0.54 1.15 0.43 0.96 0.8
rs2241261 8 C T 0.96 0.88 1.03 0.84 0.89 0.60 1.26 0.12 1.07 0.66 0.84 0.32
rs35252396a 8 A C 1.17 0.57 0.95 0.77 0.97 0.89 1.60 0.0037 0.99 0.96 1.92 0.00094
rs35252396a 8 C G 1.17 0.57 0.95 0.77 0.97 0.89 1.60 0.0037 0.99 0.96 1.92 0.00094
rs11813268 10 C T 1.15 0.64 0.85 0.42 0.54 0.06 0.88 0.50 1.02 0.93 1.14 0.54
rs7105934 11 G A 0.32 0.27 0.96 0.92 0.46 0.29 0.72 0.40 0.56 0.13 0.66 0.41
rs1800057 11 C G 1.68 0.44 1.64 0.29 0.47 0.39 0.92 0.86 1.34 0.53 0.66 0.51
rs74911261 11 G A 2.21 0.25 1.13 0.82 0.31 0.31 0.49 0.21 1.29 0.63 0.76 0.68
rs718314 12 A G 1.05 0.86 0.93 0.67 0.89 0.65 1.11 0.55 0.94 0.72 1.07 0.74
rs4765623 12 C T 1.13 0.65 0.99 0.94 0.64 0.07 1.08 0.63 0.92 0.60 0.95 0.77
rs4903064 14 T C 1.35 0.25 0.90 0.55 1.19 0.45 1.06 0.72 1.04 0.83 0.96 0.82
  1. Chrom denotes chromosome location, OR denotes odds ratio and p value is from a logistic regression model. Cells highlighted in italics denote associations that pass our multiple testing threshold (p value < (0.05/14 = 0.004). Cells highlighted in bold denote candidate associations (0.004 < p value < 0.05)
  2. ars35252396 is tri-allelic