Table 3 Diseased Hunner’s IC biopsies compared to diseased non-Hunner’s IC biopsies
Accession ID | Gene Name | Description | Fold change (FC ≥ 4) | p value (p ≤ 0.05) |
|---|---|---|---|---|
Immune and inflammatory response (up-regulated) 10 of 34 significant proteins | Diseased HIC/diseased NHIC | |||
P11678 | EPX | Eosinophil peroxidase | 74.7 | 0.0184 |
P08575 | PTPRC | Tyrosine phosphatase C | 45.9 | 0.0163 |
P12724 | RNASE3 | Eosinophil cationic protein | 19.6 | 0.0072 |
P13727 | PRG2 | Bone marrow proteoglycan precursor | 13.6 | 0.0046 |
P01889 | HLA-B | HLA class I histocompatibility antigen, B-41 | 10.5 | 0.0011 |
P51665 | PSMD7 | 26S proteasome non-ATPase regulatory subunit | 9.16 | 0.0481 |
P04440 | HLA-DPB1 | HLA class II histocompatibility antigen, DP beta 1 chain | 6.77 | 0.0079 |
Q8NBS9 | TXNDC5 | Thioredoxin domain-containing protein 5 | 5.55 | 0.0065 |
P22897 | MRC1 | Mannose-receptor C-type 1 | 5.91 | 0.0303 |
Q9Y2Y8 | PRG3 | Proteoglycan 3 | 4.46 | 0.0038 |
ER protein processing & ER stress (up-regulated) 9 of 34 significant proteins | ||||
Q8TCJ2 | STT3B | Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit STT3B | 22.2 | 0.026 |
Q9UNL2 | SSR3 | Translocon-associated protein subunit gamma | 13.6 | 0.0135 |
Q2P2E9 | RRBP1 | Ribisome-binding protein 1 | 11.2 | 0.0119 |
Q9UBS4 | DNAJB11 | DnaJ Homolong subfamily B member 11 | 11.1 | 0.0008 |
P46977 | STT3A | Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit STT3A | 8.79 | 0.0248 |
P49257 | LMAN1 | Protein ERGIC-53 | 5.97 | 0.0244 |
Q8NBS9 | TXDNC5 | Thioredoxin domain-containing protein 5 | 5.55 | 0.0065 |
Q12907 | LMAN2 | Vesicular integral-membrane protein VIP36 | 5.27 | 0.0028 |
P51571 | SSR4 | Translocon-associated protein subunit delta | 4.04 | 0.0091 |
Cellular adhesion (down-regulated) 5 of 42 significant proteins | Diseased NHIC/Diseased HIC | |||
Q14031 | COL4A6 | Collagen alpha-6(IV) | 12.6 | 0.0144 |
P35221 | CTNNA1 | Catenin alpha-1 | 9.54 | 0.0005 |
O60716 | CTNND1 | Catenin delta-1 | 5.69 | 0.0288 |
P02461 | COL3A1 | Collagen alpha-1(III) | 4.62 | 0.0039 |
Q99715 | COL12A1 | Collagen alpha-1(XII) | 4.46 | 8.13e-5 |