Table 1 Clinical manifestations of penile verrucous carcinoma

1(47)

49

12

5 × 4.5 x 2

Papillary cauliflower

Glans, coronoid sulcus,

Ta

local excision

Systemic bleomycine, methotrexate,

none

48/no

24

Anaplastic spindle cell carcinoma

Negative

1994

shaft

Radiotherapy

Malignant transformation after Radiotherapy

2(46)

62

3

3

Cauliflower-like

Prepuce, coronal sulcus

Ta

Local excision

None

None

54/yes

26

Hybrid verrucous-squamous cell carcinoma

Negative

2000

3(45)

42

4

7

Cauliflower-like

Prepuce, glans

Ta

Local excision

CO₂ laser

None

36/yes

None

None

?

2008

4(43)

51

24

?

Verrucous

Glans, coronary sulcus

Ta

Recurred mass

Liquid nitrogne, topical 5% fluorouracil

None

42/yes

None

None

?

1978

after local excision

and skin graft

after local excision

5(40)

60

?

?

?

Glans

Ta

Shaving

Intralesional interferone

None

30/yes

None

None

Negative

2000

6(39)

69

24

1

Keratotic

Glans

Ta

Shaving

Cryosurgery with liquid nitrogen

None

36/yes

None

None

?

2002

7(39)

69

24

1.5

Keratotic

Glans

Ta

Shaving

Cryosurgery with liquid nitrogen

None

36/yes

None

None

?

8(38)

27

12

5 × 5

Verrucous

gLans

Ta

None

Intra-aortic infusion with methotrexate

None

214/yes

None

None

?

2003

9(38)

65

3

4 × 3

Warty

Glans

Ta

None

Intra-aortic infusion with methotrexate

None

165/yes

None

None

?

10(38)

31

48

5 × 5

?

Shaft

Ta

Total penectomy

Intra-aortic infusion with methotrexate

None

149/yes

36/partial

None

?

due to partial response

Response

and unbarable pain

11(38)

75

120

2 × 2

?

Glans

Ta

None

Intra-aortic infusion with methotrexate

none

104/yes

None

None

?

12(37)

70

?

?

Verrucous

Shaft, base of penis

T1

Mohs surgery and FTSG

Cisplatin and fluorouracil with radiotherapy

none

36/yes

16

None

negative

2009

after recurrence (local excision)

13(35)

47

3

4 × 3

?

Prepuce, glans

Ta

Total penectomy

Intra-aortic infusion with methotrexate

Bilateral

37/no

18/partial

Moderately differentiated squamous cell

?

2010

due to partial response

Response

Carcinoma, malignant transformation?

14(35)

28

72

5 × 4.5x2

Verrucous

Prepuce, glans

Ta

None

Intra-aortic infusion with methotrexate

None

45/yes

None

None

?

15(32)

42

?

1

Warty

Glans

Ta

Mohs surgery

None (healed by secondary intention)

None

12/yes

None

Lichen sclerosus

?

1987

16(31)

74

12

2 × 1.5

Warty

Glans

Ta

Local excision

Failed cryotherapy with liquid nitrogen

None

48/yes

None

Pseudoepitheliomatous

negative

2000

Nodule

(surgical margin 2 cm)

Keratotic and micaceous balanitis

17(23)

60

7

3 × 3

Verrucous, ulcerative

Prepuce, glans

Ta

Partial penectomy

None

None

24/yes

None

Human immunodeficiency virus infection

negative

2015

18(20)

71

6

2.8 × 1.6

Keratotic hornlike

Glans

T1a

Partial penectomy

None

None

10/yes

None

None

Negative

1990

total penectomy

(due to residual tumor on the resection margins)

19(11)

61

?

7 × 4

Cauliflower-like

Shaft

T1a

Local excsion, skin graft

None

None

36/yes

None

None

?

2019

20(10)

30 to 86

at least 12

1 to 8

Warty or fungating

11 glans

10 Ta

9 partial penectomy

All none but

All

72 to 228

All

All none

All

1985

mean 47

in 10 cases

mean 3.6

(multiple nodules

2 prepuce

3 T1

3 total penectomy

1 radiotherapy

none

/yes

none

?

(in 5 cases

in 7 cases)

1 circumcision

(before total penaectomy)

13 cases

2,2,4,8,17 years)

in 3 cases

32(10)

(1,2,4 months)

33(7)

40 to 63

8 to 25

2.5 to 6.2

Cauliflower-like

Glans

Ta

Glansectomy

None

None

18 to 65

None

None

?

2001

mean 54 ± 7

with frozen section

mean 38 ± 14

34(7)

Cauliflower-like

Glans

Ta

Glansectomy

None

None

/Yes

None

None

?

35(7)

Cauliflower-like

Glans

Ta

Partial penectomy after

None

None

3

None

?

glansectomy

36(7)

Cauliflower-like

Glans

Ta

Glansectomy

None

None

None

None

?

37(6)

73

12

3

Verrucous

coronary sulcus, shaft

Ta

Local excision

None

None

24/yes

None

None

Negative

2017

38(5)

52

96

6

All

coronoid sulcus

all

Partial penectomy

All none

All

6 to 60

All

Squamous atypical hyperplasia

All

2011

39(5)

85

48

3

Exophytic papillary

Glans

Ta

Local excision

None

mean 36

None

None

?

40(5)

55

24

5

Cauliflower-like

Coronoid sulcus

Partial penectomy

/yes

None

41(5)

64

3

2

Glans

Partial penectomy

None

42(5)

74

3

3

Glans

Local excision

Squamous papilloma

43(5)

56

12

2

Glans

Local excsion

Squamous atypical hyperplasia

44(5)

52

3

2.5

Coronoid sulcus

Partial penectomy

None

45(5)

55

24

10

Shaft

Partial penectomy

Squamous atypical hyperplasia

46(5)

68

60

2

Coronoid sulcus

Circumcision,

Surgical margin 2 cm for partial penectomy

None

Partial penectomy

0.5–1 cm for local excision

47(5)

70

6

4.5

Glans

Partial penectomy

Acknowledging excessive resection in 3 cases

None

48(5)

49

3

3

Glans

Partial penectomy

For the small-sized mass limited to glans

None

49(4)

35 to 72

All ?

0.8 to 4

All

5 prepuce

All

All

All none

All

8 to 108

All

All

All

2015

50(4)

mean 51.5

Cauliflower-like

1 prepuce, coronoid sulcus

Ta

Partial penectomy

None

/Yes

but 1 case

but 1 squamous metaplasia with

?

51(4)

1 glans, coronoid sulcus

36, 60, 84

partial hyperkeratosis

52(4)

3 glans

53(4)

54(4)

10 cases

55(4)

56(4)

57(4)

8 Biopsy before surgical treatment

58(4)

2 circumcision before surgical treatment