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Table 3 Univariate Cox regression analysis of prognostic factors correlated with overall survival and progression-free survival

From: Preoperative anaemia and thrombocytosis predict adverse prognosis in non‐metastatic renal cell carcinoma with tumour thrombus

Variable

Overall survival

Progression-free survival

HR

95 %CL

P-value

HR

95 %CL

P-value

Age*

0.980

0.943–1.018

0.289

0.976

0.950–1.003

0.086

Sex (male vs. female)

      

Male

Ref

  

Ref

  

Female

0.874

0.330–2.315

0.787

0.801

0.390–1.645

0.545

ASA score

      

I + II

Ref

  

Ref

  

III

1.511

0.518–4.412

0.450

1.110

0.471–2.613

0.812

Symptom at presentation

1.858

0.745–4.629

0.184

1.878

0.978–3.603

0.058

Histologic subtype

      

CCRCC

Ref

  

Ref

  

Non-CCRCC

2.279

0.909–5.716

0.079

3.007

1.620–5.845

0.001

Tumour thrombus level

      

0–II

Ref

  

Ref

  

III–IV

1.259

0.525–3.022

0.606

1.149

0.609–2.167

0.669

Tumour size*

1.032

0.910–1.170

0.626

1.015

0.926–1.113

0.749

Invasion of venous wall

1.455

0.681–3.112

0.333

1.450

0.824–2.551

0.198

Nuclear grade

      

I–II

Ref

  

Ref

  

III–IV

2.283

0.955–5.456

0.063

2.368

1.255–4.468

0.008

Lymph node metastasis

5.622

1.872–16.888

0.002

3.871

1.504–9.962

0.005

Necrosis

1.889

0.850–4.198

0.119

1.709

0.946–3.028

0.066

SSIGN score

      

Low-risk (score 2–4)

Ref

  

Ref

  

Intermediate-risk (score 5–7)

2.158

0.771–6.039

0.143

2.311

1.125–4.749

0.023

High-risk (score 8–11)

5.653

1.808–17.677

0.003

3.799

1.598–9.033

0.003

Blood parameters

      

NLR*

1.090

0.959–1.239

0.189

1.019

0.905–1.148

0.750

PLR*

1.001

0.998–1.004

0.377

1.002

1.000–1.004

0.084

AST/ALT*

1.117

0.553–2.256

0.758

1.212

0.983–1.765

0.238

Thrombocytosis

2.288

0.946–5.532

0.066

3.307

1.819–6.009

< 0.001

Anaemia

2.991

1.384–6.467

0.005

2.065

1.196–3.566

0.009

ALB*

0.959

0.902–1.021

0.191

0.979

0.935–1.026

0.384

SCR*

1.003

0.987–1.019

0.714

0.994

0.981–1.007

0.376

SCa*

0.666

0.064–6.885

0.733

3.740

0.769–18.205

0.102

ALP*

1.006

0.998–1.013

0.150

1.001

0.995–1.008

0.638

  1. *As continuous variable
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