GROUP/HOURS | PTX | DTX | PTX + DTX |
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2 mM | 4 mM | 8 mM | 15 nM | 25 nM | 4 mM/25 nM | 8 mM/25 nM |
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24 | 70.0 ± 3.6 | 34.7 ± 8.2+ | 26.3 ± 2.6+ | 87.3 ± 2.1 | 45.8 ± 2.5 | 24.7 ± 2.5+ | 22.3 ± 3.2+ |
48 | 61.7 ± 4.2 | 29.4 ± 3.3+ | 19.7 ± 3.1+ | 69.5 ± 2.1 | 42.3 ± 7.4 | 23.7 ± 2.5+ | 21.3 ± 4.2+ |
72 | 59.1 ± 2.2 | 20.7 ± 1.5+ | 17.3 ± 3.5+ | 62.3 ± 3.2 | 25.7 ± 2.1 | 19.2 ± 2.3+ | 17.3 ± 1.5+ |
- PTX decreases viability, alone or in combination with DTX, in PC3 cells after 24, 48, and 72 h of treatment. A total of 3 × 104 PC3 cells were seeded and were initially treated (24 h prior) with different concentrations of PTX and DTX, alone or combined. Later, cell viability was evaluated by WST-1 assays. The results represent the mean ± SD of the values obtained of three experiments carried out in triplicate. Untreated control cells were considered as 100%. + Mann‒Whitney U test, p < 0.05 versus DTX-treated groups