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Table 8 Incidence of symptomatic UTI with bacteriuria at 24 weeks by study arm

From: High dose versus low dose standardized cranberry proanthocyanidin extract for the prevention of recurrent urinary tract infection in healthy women: a double-blind randomized controlled trial

 

Low dose group, 2 × 1 mg PAC

High dose group, 2 × 18.5 mg PAC

Incidence rate ratio (95% CI)

p value

Symptomatic UTI with bacteriuria, episodes, n (%)a

n = 73

n = 72

 

 0

55 (75.3)

63 (87.5)

 

 1

17 (23.3)

7 (9.7)

 

 2

1 (1.4)

2 (2.8)

 

  ≥ 1

18 (24.7)

9 (12.5)

 

Total symptomatic UTIs with bacteriuria, episodes

19

11

 

Total person-days

10,997

11,088

 

Symptomatic UTI with bacteriuria, annualized incidence density (95% CI)

0.63 (0.40–0.99)

0.36 (0.20–065)

0.57 (0.27–1.21)

p = 0.14

Symptomatic UTI with bacteriuria, age-adjusted annualized incidence density (95% CI)

0.76 (0.48–1.21)

0.53 (0.27–1.02)

0.69 (0.32–1.49)

p = 0.34

Subgroup analyses In women with < 5 UTI in past 12 months

n = 46

n = 51

 

Symptomatic UTI with bacteriuria

14

5

 

Symptomatic UTI with bacteriuria, annualized incidence density (95% CI)

0.70 (0.42–1.18)

0.23 (0.10–0.55)

0.33 (0.12–0.91)

p = 0.03

Symptomatic UTI with bacteriuria, age-adjusted annualized incidence density (95% CI)

0.85 (0.50–1.43)

0.35 (0.14–0.89)

0.41 (0.14–1.19)

p = 0.10

Subjects reporting symptomatic UTI with bacteriuria, episodes, n %)b

   

 0

42 (57.5)

51 (70.8)

 

 1

22 (30.1)

15 (20.8)

 

 2

6 (8.2)

4 (5.6)

 

 3

3 (4.1)

1 (1.4)

 

 4

0 (0.0)

1 (1.4)

 

  ≥ 1

31 (42.5)

21 (29.2)

 

Total symptomatic UTIs with bacteriuria, episodes

43

30

 

Total person-days

10,997

11,088

 

Symptomatic UTI with bacteriuria, annualized incidence density (95% CI)

1.43 (1.06–1.93)

0.99 (0.69–1.41)

0.69 (0.43–1.10)

p = 0.12

Symptomatic UTI with bacteriuria, age-adjusted annualized incidence density (95% CI)

1.71 (1.26–2.33)

1.40 [0.93–2.10)

0.81 (0.50–1.32)

p = 0.40

Subgroup analyses In women with < 5 UTI in past 12 months

n = 46

n = 51

 

Symptomatic UTI with bacteriuria

28

13

 

Symptomatic UTI with bacteriuria, annualized incidence density (95% CI)

1.40 (0.97–2.03)

0.60 (0.35–1.03)

0.43 (0.22–0.83)

p = 0.01

Symptomatic UTI with bacteriuria, age-adjusted annualized incidence density (95% CI)

1.70 (1.17–2.46)

0.93 (0.52–1.66)

0.55 (0.28–1.08)

p = 0.08

  1. aSymptomatic UTI episodes without urine sample were considered as no symptomatic UTI with uropathogenic bacteriuria > 103 CFU/ml
  2. bSymptomatic UTI episodes without urine sample were considered as symptomatic UTI with uropathogenic bacteriuria > 103 CFU/ml