Low dose group, 2 × 1 mg PAC | High dose group, 2 × 18.5 mg PAC | Incidence rate ratio (95% CI) p value | |
---|---|---|---|
Symptomatic UTI with bacteriuria, episodes, n (%)a | n = 73 | n = 72 | |
0 | 55 (75.3) | 63 (87.5) | |
1 | 17 (23.3) | 7 (9.7) | |
2 | 1 (1.4) | 2 (2.8) | |
≥ 1 | 18 (24.7) | 9 (12.5) | |
Total symptomatic UTIs with bacteriuria, episodes | 19 | 11 | |
Total person-days | 10,997 | 11,088 | |
Symptomatic UTI with bacteriuria, annualized incidence density (95% CI) | 0.63 (0.40–0.99) | 0.36 (0.20–065) | 0.57 (0.27–1.21) p = 0.14 |
Symptomatic UTI with bacteriuria, age-adjusted annualized incidence density (95% CI) | 0.76 (0.48–1.21) | 0.53 (0.27–1.02) | 0.69 (0.32–1.49) p = 0.34 |
Subgroup analyses In women with < 5 UTI in past 12 months | n = 46 | n = 51 | |
Symptomatic UTI with bacteriuria | 14 | 5 | |
Symptomatic UTI with bacteriuria, annualized incidence density (95% CI) | 0.70 (0.42–1.18) | 0.23 (0.10–0.55) | 0.33 (0.12–0.91) p = 0.03 |
Symptomatic UTI with bacteriuria, age-adjusted annualized incidence density (95% CI) | 0.85 (0.50–1.43) | 0.35 (0.14–0.89) | 0.41 (0.14–1.19) p = 0.10 |
Subjects reporting symptomatic UTI with bacteriuria, episodes, n %)b | |||
0 | 42 (57.5) | 51 (70.8) | |
1 | 22 (30.1) | 15 (20.8) | |
2 | 6 (8.2) | 4 (5.6) | |
3 | 3 (4.1) | 1 (1.4) | |
4 | 0 (0.0) | 1 (1.4) | |
≥ 1 | 31 (42.5) | 21 (29.2) | |
Total symptomatic UTIs with bacteriuria, episodes | 43 | 30 | |
Total person-days | 10,997 | 11,088 | |
Symptomatic UTI with bacteriuria, annualized incidence density (95% CI) | 1.43 (1.06–1.93) | 0.99 (0.69–1.41) | 0.69 (0.43–1.10) p = 0.12 |
Symptomatic UTI with bacteriuria, age-adjusted annualized incidence density (95% CI) | 1.71 (1.26–2.33) | 1.40 [0.93–2.10) | 0.81 (0.50–1.32) p = 0.40 |
Subgroup analyses In women with < 5 UTI in past 12 months | n = 46 | n = 51 | |
Symptomatic UTI with bacteriuria | 28 | 13 | |
Symptomatic UTI with bacteriuria, annualized incidence density (95% CI) | 1.40 (0.97–2.03) | 0.60 (0.35–1.03) | 0.43 (0.22–0.83) p = 0.01 |
Symptomatic UTI with bacteriuria, age-adjusted annualized incidence density (95% CI) | 1.70 (1.17–2.46) | 0.93 (0.52–1.66) | 0.55 (0.28–1.08) p = 0.08 |