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Table 1 Ten studies of HPD involved radiotherapy

From: Hyperprogressive disease after radiotherapy combined with anti-PD-1 therapy in renal cell carcinoma: a case report and review of the literature

Year

Author

Tumor types

The number of cases of HPD

Radiotherapy strategy

Type of ICB

Relationship between radiotherapy and HPD

2016

Champiat [9]

Solid tumors

12

Not described

Anti-PD-1 Anti-PD-L1

Unrelated

2016

Alexander [14]

Renal cancer

1

20 Gy in 5 fractions

Anti-PD-1

Unrelated

2017

Kato [15]

Endometrial stromal sarcoma

1

SBRT

Anti-PD-1

Not described

  

Breast cancer

1

Not described

Anti-PD-1

Not described

2017

Saâda-Bouzid [13]

Head and neck cancers

10

Not described

Anti-PD-1 Anti-PD-L1

Related

2017

Yoshida T [16]

Lung cancer

1

60 Gy

Anti-PD-1

Related

2018

Ogata [17]

Gastric cancer

1

50.4 Gy in 28 fractions

Anti-PD-1

Related

2018

Du [18]

Lung cancer

1

8 Gy in 1 fraction

Anti-PD-1

Related

2018

Ferrara [12]

Lung cancer

56

Not described

Anti-PD-1 Anti-PD-L1

Not described

2019

Yilmaz [19]

Melanoma

1

Not described

Anti-PD-1

Related

2019

Bosch-Barrera [20]

Lung cancer

1

8 Gy in 1 fraction

Anti-PD-L1

Not described