Body size throughout the life-course and incident benign prostatic hyperplasia-related outcomes and nocturia

Khan, Saira; Wolin, K. Y.; Pakpahan, R.; Grubb, R. L.; Colditz, G. A.; Ragard, L.; Mabie, J.; Breyer, B. N.; Andriole, G. L.; Sutcliffe, S.

doi:10.1186/s12894-021-00816-5

BMC Urology

Table 5 Age-adjusted risk ratios (RRs) and 95% confidence intervals (CIs) of incident benign prostatic hyperplasia (BPH)-related outcomes and nocturia by weight change across the life-course; Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

From: Body size throughout the life-course and incident benign prostatic hyperplasia-related outcomes and nocturia

	Loss > 5		Loss or gain of 5		Gain 5–14		Gain 15–24		Gain 25–34		Gain 35–44		Gain 45–54		Gain 55–64		Gain 65–74		Gain ≥ 75		p-trend^a
	RR	95% CI	RR	95% CI	RR	95% CI	RR	95% CI	RR	95% CI	RR	95% CI	RR	95% CI	RR	95% CI	RR	95% CI	RR	95% CI	p-trend^a
Weight change from age 20 to baseline (lbs)
All participants
Nocturia^a	1.15	0.89, 1.48	1.00	Referent	0.96	0.78, 1.18	1.00	0.82, 1.21	1.05	0.87, 1.28	1.08	0.89, 1.32	1.13	0.92, 1.39	1.33	1.07, 1.64	1.16	0.90, 1.49	1.21	0.96, 1.52	0.0028
No. of cases	68		93		183		241		254		219		169		128		67		93
Prostate volume ≥ 30 cc ^b	1.09	0.93, 1.28	1.00	Referent	1.11	0.98, 1.25	1.10	0.97, 1.24	1.08	0.95, 1.21	1.14	1.00, 1.28	1.16	1.02, 1.32	1.10	0.96, 1.27	1.13	0.96, 1.32	1.11	0.95, 1.29	0.18
No. of cases	106		155		349		431		428		363		273		170		102		122
Restricted to those who did not change body mass index category from age 20 to baseline
Nocturia^a	1.09	0.79, 1.50	1.00	Referent	0.93	0.74, 1.16	1.04	0.83, 1.31	0.94	0.70, 1.25	0.90^a	0.64, 1.25									0.97
No. of cases	40		88		134		137		69		51
Prostate volume ≥ 30 cc ^b	1.10	0.90, 1.33	1.00	Referent	1.06	0.92, 1.21	1.07	0.93, 1.23	1.02	0.85, 1.22	0.92^a	0.75–1.13									0.76
No. of cases	66		147		258		227		121		81
Weight change from age 50 to baseline (lbs)
All participants
Nocturia ^a	1.10	0.89, 1.35	1.00	Referent	0.99	0.89, 1.11	1.17	0.96, 1.42	1.23	0.90, 1.68	1.38 ^a	1.01, 1.90									0.0039
No. of cases	194		434		456		242		97		92
Prostate volume ≥ 30 cc ^b	1.03	0.91, 1.16	1.00	Referent	1.02	0.95, 1.08	1.04	0.92, 1.16	0.93	0.77, 1.14	1.14 ^a	0.83, 1.01									0.32
No. of cases	310		777		807		373		125		107
Restricted to those who did not change body mass index category from age 50 to baseline
Nocturia^a	1.06	0.78, 1.44	1.00	Referent	1.07	0.90, 1.27	1.07^a	0.80, 1.42													0.28
No. of cases	85		242		155		37
Prostate volume ≥ 30 cc ^b	0.99	0.83, 1.19	1.00	Referent	1.03	0.93, 1.14	1.03^a	0.87, 1.23													0.25
No. of cases	146		436		263		55

^aIncludes values of weight gain greater than the upper bound of the weight category

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